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Anti-DC-SIGNR1/CD209b Polyclonal Antibody
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Catalog No. TMAB-05016
Anti-DC-SIGNR1/CD209b Polyclonal Antibody is a Rabbit antibody targeting DC-SIGNR1/CD209b. Anti-DC-SIGNR1/CD209b Polyclonal Antibody can be used in WB.
Anti-DC-SIGNR1/CD209b Polyclonal Antibody
Anti-DC-SIGNR1/CD209b Polyclonal Antibody
😃Good
Catalog No. TMAB-05016
Anti-DC-SIGNR1/CD209b Polyclonal Antibody is a Rabbit antibody targeting DC-SIGNR1/CD209b. Anti-DC-SIGNR1/CD209b Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-DC-SIGNR1/CD209b Polyclonal Antibody is a Rabbit antibody targeting DC-SIGNR1/CD209b. Anti-DC-SIGNR1/CD209b Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane Single-pass type II membrane protein |
| Tissue Specificity | Expressed in skin, spleen and lung, probably in a subset of dendritic cells. Detected in spleen extrafollicular paracortical areas including the red pulp and marginal zones, and at lower levels, in the follicular area. Detected in skin suprabasal areas adjacent to the epidermis and in epidermal cell layer. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Antigen-presenting cells are localized in essentially every tissue, where they operate at the interface of innate and acquired immunity by capturing pathogens and presenting pathogen-derived peptides to T cells. Dendritic cells capture antigens or viruses in peripheral tissue and transport them to lymphoid organs, an event that induces cellular T cell responses. The mouse CD209 family of cell adhesion receptors consists of CD209a (also known as DC-SIGN), CD209b, CD209c, CD209d, CD209e, CD209f and CD209g, all of which function to mediate the endocytosis and subsequent degradation of pathogens within lysosomal compartments. There are two human CD209 proteins, designated DC-SIGN and DC-SIGNR, which function in a similar manner to the mouse proteins. |
| Immunogen | KLH conjugated synthetic peptide: mouse CD209b |
| Antigen Species | Mouse |
| Gene Name | Cd209b |
| Gene ID | |
| Protein Name | CD209 antigen-like protein B |
| Uniprot ID | |
| Function | SIGN R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in some strains, in the peritoneal cavity. MZM of the spleen are involved in the clearance of polysaccharides. Mouse SIGN R1 is a C type lectin, like DC SIGN which is expressed on Human dendritic cells (DCs). However, Mmouse SIGN R1 itself is not expressed on DCs. SIGN R1 exists in an aggregated form, resistant to dissociation into monomers upon boiling in SDS under reducing conditions. SIGN R1 mediates the uptake of encapsulated organisms and may be an important mediator for the uptake of microbes in both spleen and lymph node, particularly through the recognition of microbial polysaccharides. |
| Molecular Weight | Theoretical: 37 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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