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Anti-CLDN1 Antibody (7K221)
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Catalog No. TMAB-04436
Anti-CLDN1 Antibody (7K221) is a Rabbit antibody targeting CLDN1. Anti-CLDN1 Antibody (7K221) can be used in WB.
Anti-CLDN1 Antibody (7K221)
Anti-CLDN1 Antibody (7K221)
Copy Product Info😃Good
Catalog No. TMAB-04436
Anti-CLDN1 Antibody (7K221) is a Rabbit antibody targeting CLDN1. Anti-CLDN1 Antibody (7K221) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-CLDN1 Antibody (7K221) is a Rabbit antibody targeting CLDN1. Anti-CLDN1 Antibody (7K221) can be used in WB. |
| Ig Type | IgG |
| Clone | 7K221 |
| Reactivity | Human,Mouse |
| Verified Activity | Sample: Lane 1: Mouse Skin tissue lysates Lane 2: Human HepG2 cell lysates Primary: Anti-CLDN1 (TMAB-04436) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: kDa Observed band size: 18 kDa 2. 25 μg total protein per lane of various lysates (see on figure) probed with CLDN1 monoclonal antibody, unconjugated (TMAB-04436) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Widely expressed, with highest levels in liver and kidney. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008] |
| Immunogen | A synthesized peptide: human Claudin 1 |
| Gene Name | CLDN1 |
| Gene ID | |
| Protein Name | Claudin-1 |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
| Molecular Weight | Theoretical: 23 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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