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Mal-amido-PEG4-NHS ester

Name: Mal-amido-PEG4-NHS ester
Brand: TargetMol
SKU: T15956
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15956Cas No. 756525-99-2

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker suitable for use in PROTAC synthesis [1].

Mal-amido-PEG4-NHS ester

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Purity: 95%

Catalog No. T15956Cas No. 756525-99-2

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker suitable for use in PROTAC synthesis [1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock

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Purity:95%

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker suitable for use in PROTAC synthesis [1].
In vitro	PROTACs, comprising two ligands linked together—one for an E3 ubiquitin ligase and the other for the target protein—leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	513.49
Formula	C₂₂H₃₁N₃O₁₁
Cas No.	756525-99-2
Smiles	C(CC(NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O)=O)N2C(=O)C=CC2=O
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9475 mL	9.7373 mL	19.4746 mL	97.3729 mL
5 mM	0.3895 mL	1.9475 mL	3.8949 mL	19.4746 mL
10 mM	0.1947 mL	0.9737 mL	1.9475 mL	9.7373 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc