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Anti-FZD7 Antibody represents a highly specialized monoclonal antibody specifically engineered to target the human Frizzled-7 receptor with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of Wnt ligand interaction across various preclinical experimental models to evaluate the inhibition of canonical beta-catenin signaling and tumor-initiating cell frequency during strictly monitored laboratory observation periods in advanced oncology research environments.

| Description | Anti-FZD7 Antibody represents a highly specialized monoclonal antibody specifically engineered to target the human Frizzled-7 receptor with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of Wnt ligand interaction across various preclinical experimental models to evaluate the inhibition of canonical beta-catenin signaling and tumor-initiating cell frequency during strictly monitored laboratory observation periods in advanced oncology research environments. |
| In vitro | In CRISPR screen validation and Wnt signaling assays, Anti-FZD7 Antibody blocked Wnt-FZD5 signaling and inhibited the growth of RNF43-mutant pancreatic tumor cells [1]. |
| In vivo | In RNF43-mutant pancreatic cancer xenograft models, systemic administration of Anti-FZD7 Antibody significantly reduced tumor burden and inhibited Wnt signaling in vivo [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | FZD7 |
| Isotype | IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
| Size | Quantity | Unit Price | Amount | Operation |
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