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JNK Inhibitor VIII

Name: JNK Inhibitor VIII
Brand: TargetMol
SKU: T7677
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7677Cas No. 894804-07-0

Alias TCS JNK 6o

JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive, selective inhibitor of c-Jun N-terminal kinase (JNK) with IC50 values of 45 nM for JNK-1 and 160 nM for JNK-2.

JNK Inhibitor VIII

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Purity: 98.93%

Catalog No. T7677Alias TCS JNK 6oCas No. 894804-07-0

JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive, selective inhibitor of c-Jun N-terminal kinase (JNK) with IC50 values of 45 nM for JNK-1 and 160 nM for JNK-2.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$347	In Stock	In Stock
50 mg	$516	In Stock	In Stock
100 mg	$736	In Stock	-
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.93%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

JNK Inhibitor VIII AI Summary

JNK Inhibitor VIII exhibits significant bioactivity, prominently as an inhibitor of JNK1, JNK2, and JNK3-mediated ATF2 phosphorylation, with Ki values of 2.0 nM, 4.0 nM, and 52.0 nM, respectively. It also inhibits cJun phosphorylation in the HepG2 cell line with EC50 values ranging from 4.0 nM to 920.0 nM. Although its inhibitory effect on a broad spectrum of kinases can vary, it demonstrates Ki values exceeding 700 nM for CDK2, Abl, p38-gamma, TrkA, PKA, EGFR, ErbB2, and others. Moreover, it shows moderate inhibition of Flt1 with a Ki value over 400 nM. Additionally, the compound presents pharmacokinetic properties including a half-life of approximately 1.1-1.4 hours, oral bioavailability of 2.7%, and a volume of distribution at steady state of 1.2 L.kg⁻¹. Notably, its bioactivity includes inhibiting JAK3 enzyme activity with residual activity below 65% at a 100 μM concentration. These characteristics indicate that JNK Inhibitor VIII could significantly impact multiple signaling pathways, especially the JNK signaling pathway..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive, selective inhibitor of c-Jun N-terminal kinase (JNK) with IC50 values of 45 nM for JNK-1 and 160 nM for JNK-2.
Targets&IC50	JNK2:160 nM, JNK2:4 nM (Ki), JNK3:52 nM (Ki), JNK1:45 nM, JNK1:2 nM (Ki)
Synonyms	TCS JNK 6o

Chemical Properties

Molecular Weight	356.38
Formula	C₁₈H₂₀N₄O₄
Cas No.	894804-07-0
Smiles	CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (70.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8060 mL	14.0300 mL	28.0599 mL	140.2997 mL
5 mM	0.5612 mL	2.8060 mL	5.6120 mL	28.0599 mL
10 mM	0.2806 mL	1.4030 mL	2.8060 mL	14.0300 mL
20 mM	0.1403 mL	0.7015 mL	1.4030 mL	7.0150 mL
50 mM	0.0561 mL	0.2806 mL	0.5612 mL	2.8060 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc