Home Tools
Log in
Cart

APE Protein, Human, Recombinant

Catalog No. TMPJ-00464
Synonyms: APEX, Apurinic-Apyrimidinic Endonuclease 1, APEN, DNA-(Apurinic or Apyrimidinic Site) Lyase, AP Endonuclease 1, APE1, Redox Factor-1, REF1, APE-1REF-1, HAP1, APX, APE, APEX1, APEX Nuclease

Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
APE Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 129.00
50 μg 5 days $ 390.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
Bulk Inquiry
Get quote
Contact us for more batch information
Biological Description
Technical Params
Product Properties
Description Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
Species Human
Expression System E. coli
Tag None
Accession Number AAH02338.1
Synonyms APEX, Apurinic-Apyrimidinic Endonuclease 1, APEN, DNA-(Apurinic or Apyrimidinic Site) Lyase, AP Endonuclease 1, APE1, Redox Factor-1, REF1, APE-1REF-1, HAP1, APX, APE, APEX1, APEX Nuclease
Amino Acid Pro2-Leu318
Construction Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 40 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Research Background Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

Calculator

Reconstitution Calculator
Recombinant Proteins Dilute Calculator
Specific Activity Calculator
=
÷
X
=
X
(Unit/mg)
= 106 ÷
ng/mL

bottom

Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

APE Protein, Human, Recombinant APEX HAP 1 Apurinic-Apyrimidinic Endonuclease 1 HAP-1 APEN DNA-(Apurinic or Apyrimidinic Site) Lyase AP Endonuclease 1 APE1 Redox Factor-1 REF1 APE 1 APE-1REF-1 HAP1 REF-1 APEX 1 APX APE APE-1 APEX-1 REF 1 APEX1 APEX Nuclease recombinant recombinant-proteins proteins protein

 

TargetMol