APE Protein, Human, Recombinant

Name: APE Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPJ-00464
Rating: 4.5 (1 reviews)

(Synonyms: REF1, Redox Factor-1, HAP1, DNA-(Apurinic or Apyrimidinic Site) Lyase, APX, Apurinic-Apyrimidinic Endonuclease 1, APEX1, APEX Nuclease, APEX, APEN, APE-1REF-1, APE1, APE, AP Endonuclease 1) Copy Product Info

Synonyms: REF1, Redox Factor-1, HAP1, DNA-(Apurinic or Apyrimidinic Site) Lyase, APX, Apurinic-Apyrimidinic Endonuclease 1, APEX1, APEX Nuclease, APEX, APEN, APE-1REF-1, APE1, APE, AP Endonuclease 1

Catalog No. TMPJ-00464 Copy Product Info

Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

Pack Size	Price	USA Stock	Global Stock
10 µg	$129	7-10 days	7-10 days
20 µg	$198	7-10 days	7-10 days
50 µg	$390	7-10 days	7-10 days
100 µg	$626	7-10 days	7-10 days
200 µg	$987	7-10 days	7-10 days
500 µg	$1,900	7-10 days	7-10 days
1 mg	$2,730	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	AAH02338.1
Amino Acid	Pro2-Leu318
Construction	Pro2-Leu318
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 100 mM KCl, 50% Glycerol, pH 7.4.
Synonyms	REF1, Redox Factor-1, HAP1, DNA-(Apurinic or Apyrimidinic Site) Lyase, APX, Apurinic-Apyrimidinic Endonuclease 1, APEX1, APEX Nuclease, APEX, APEN, APE-1REF-1, APE1, APE, AP Endonuclease 1
Research Background	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

Chemical Properties

Molecular Weight

40 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.