Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing noradrenergic neurotransmission by blocking neuronal reuptake. Additionally, it acts as a histamine H1-receptor antagonist and lacks cardiotoxicity. Its analgesic efficacy is noted in conditions such as psychogenic facial pain, idiopathic fibromyalgia syndrome, and rheumatoid arthritis [1].
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Description | Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing noradrenergic neurotransmission by blocking neuronal reuptake. Additionally, it acts as a histamine H1-receptor antagonist and lacks cardiotoxicity. Its analgesic efficacy is noted in conditions such as psychogenic facial pain, idiopathic fibromyalgia syndrome, and rheumatoid arthritis [1]. |
Synonyms | Dosulepin, Dothep |
Molecular Weight | 295.44 |
Formula | C19H21NS |
CAS No. | 113-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Dothiepin 113-53-1 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Dosulepin Dothep inhibitor inhibit