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JNJ-10311795
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Catalog No. T27660Cas No. 518062-14-1
Alias RWJ-355871, RWJ355871, JNJ10311795
JNJ-10311795 (RWJ-355871) is a potent dual inhibitor of neutrophil elastase (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM) with significant anti-inflammatory activity, useful for studying pneumonia.
JNJ-10311795
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Purity: 97.43%
Catalog No. T27660Alias RWJ-355871, RWJ355871, JNJ10311795Cas No. 518062-14-1
JNJ-10311795 (RWJ-355871) is a potent dual inhibitor of neutrophil elastase (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM) with significant anti-inflammatory activity, useful for studying pneumonia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | In Stock | In Stock | |
| 5 mg | $722 | In Stock | In Stock | |
| 10 mg | $987 | In Stock | In Stock | |
| 25 mg | $1,520 | In Stock | In Stock | |
| 50 mg | $1,980 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:97.43%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | JNJ-10311795 (RWJ-355871) is a potent dual inhibitor of neutrophil elastase (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM) with significant anti-inflammatory activity, useful for studying pneumonia. |
| Targets&IC50 | Cathepsin G:82 nM |
| In vitro | JNJ-10311795 is a novel effective dual inhibitor of neutrophil cathepsin G (K (i) = 38 nM, IC50 = 82 nM) and mast cell rennet (K (i) = 2.3 nM). [1] |
| In vivo | In a rat model of inflammation, JNJ-10311795 (0.5 mg/kg intravenously) was administered 30 minutes before glycogen therapy, followed by 10 mg/kg/h intravenous infusion for 4.5 hours (total dose = 45.5 mg/kg). The increase in myeloperoxidase was reduced by 50% (neutrophil counts were reduced by 50%). [1] |
| Synonyms | RWJ-355871, RWJ355871, JNJ10311795 |
| Molecular Weight | 670.69 |
| Formula | C40H35N2O6P |
| Cas No. | 518062-14-1 |
| Smiles | O=C(C=1C=CC=2C=CC=CC2C1)N3CCC(N(C(=O)C4=CC=5C=CC=CC5C=C4C(=O)C(C6=CC=CC=7C=CC=CC76)P(=O)(O)O)C)CC3 |
| Relative Density. | 1.41 g/cm3 (Predicted) |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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