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(S)-3-Hydroxyphenylglycine
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Catalog No. T23291Cas No. 71301-82-1
(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).
(S)-3-Hydroxyphenylglycine
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Purity: 99.65%
Catalog No. T23291Cas No. 71301-82-1
(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $54 | In Stock | In Stock | |
| 5 mg | $111 | In Stock | In Stock | |
| 10 mg | $158 | In Stock | In Stock | |
| 25 mg | $263 | In Stock | In Stock | |
| 50 mg | $377 | In Stock | In Stock | |
| 100 mg | $517 | In Stock | In Stock | |
| 200 mg | $695 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.65%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs). |
| In vitro | Hippocampal neurons in the slice preparation exhibit spontaneous synchronized bursting activity in the presence of picrotoxin, a γ-aminobutyric acid-A receptor antagonist. These synchronized bursts rarely exceed 500 ms in duration and thus resemble interictal discharges. Control shows one such synchronized burst, which typically consisted of an initial abrupt discharge 100–200 ms in duration (primary burst) followed by a series of briefer phasic discharges (secondary bursts). Addition of (S)-3-hydroxyphenylglycine (250–500 μM) significantly prolonged the synchronized burst duration, primarily via a marked increase in the number of secondary bursts. These prolonged discharges ranged from 1 to 7 s in duration (4,282 ± 1,060 ms, a 1,021?± 247% increase, n = 7), and the secondary bursts within each discharge gradually changed in amplitude and frequency[2]. |
| Molecular Weight | 167.16 |
| Formula | C8H9NO3 |
| Cas No. | 71301-82-1 |
| Smiles | N[C@H](C(O)=O)c1cccc(O)c1 |
| Relative Density. | 1.396 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble)  H2O: 6.56 mg/mL (39.24 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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