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Sari 59-801

Name: Sari 59-801
Brand: TargetMol
SKU: T34532
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T34532Cas No. 80565-58-8

Alias Sari-59-801

Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release. SARI-59-801 was more potent in producing hypoglycemia (ED25 = 47 mg/kg) than their lean littermates (ED25 = 131 mg/kg).

Sari 59-801

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Purity: 99.92%

Catalog No. T34532Alias Sari-59-801Cas No. 80565-58-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$115	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$292	In Stock	In Stock
50 mg	$407	In Stock	In Stock
100 mg	$547	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release. SARI-59-801 was more potent in producing hypoglycemia (ED25 = 47 mg/kg) than their lean littermates (ED25 = 131 mg/kg).
In vivo	The 2-hr hypoglycemic ED25 in fasting mice was 110 mg/kg; the plasma insulin levels were increased, with an ED50 of 47 mg/kg. The significant hypoglycemic activity was observed 2 hr after oral administration of Sari 59-801 to fasting rats (ED25 = 86 mg/kg), while plasma insulin was elevated by 62% at 100 mg/kg.
Synonyms	Sari-59-801

Chemical Properties

Molecular Weight	313.39
Formula	C₁₈H₂₃N₃O₂
Cas No.	80565-58-8
Smiles	C(CN(C)C)(O)C1=C(NC=2C1=CC=CC2)C=3C(CC)=NOC3C
Relative Density.	1.188g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (207.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1909 mL	15.9546 mL	31.9091 mL	159.5456 mL
5 mM	0.6382 mL	3.1909 mL	6.3818 mL	31.9091 mL
10 mM	0.3191 mL	1.5955 mL	3.1909 mL	15.9546 mL
20 mM	0.1595 mL	0.7977 mL	1.5955 mL	7.9773 mL
50 mM	0.0638 mL	0.3191 mL	0.6382 mL	3.1909 mL
100 mM	0.0319 mL	0.1595 mL	0.3191 mL	1.5955 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc