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Anti-Phospho-eNOS (Ser1177) Antibody (4B383)

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Catalog No. TMAB-10646

Anti-Phospho-eNOS (Ser1177) Antibody (4B383) is a Rabbit antibody targeting Phospho-eNOS (Ser1177). Anti-Phospho-eNOS (Ser1177) Antibody (4B383) can be used in IHC-P,IHC-Fr,IF.

Anti-Phospho-eNOS (Ser1177) Antibody (4B383)

Anti-Phospho-eNOS (Ser1177) Antibody (4B383)

😃Good
Catalog No. TMAB-10646
Anti-Phospho-eNOS (Ser1177) Antibody (4B383) is a Rabbit antibody targeting Phospho-eNOS (Ser1177). Anti-Phospho-eNOS (Ser1177) Antibody (4B383) can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1507-10 days7-10 days
50 μL$2647-10 days7-10 days
100 μL$4737-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Phospho-eNOS (Ser1177) Antibody (4B383) is a Rabbit antibody targeting Phospho-eNOS (Ser1177). Anti-Phospho-eNOS (Ser1177) Antibody (4B383) can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Clone
4B383
Reactivity
Human
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Tissue SpecificityPlatelets, placenta, liver and kidney.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundNitric oxide synthase NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti tumor and anti pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS) or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial NOS (eNOS).
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human eNOS around the phosphorylation site of Ser1177:
Antigen Species
Human
Gene Name
NOS3
Gene ID
Protein Name
Nitric oxide synthase, endothelial
Uniprot ID
Function
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Chemical Properties
Molecular WeightTheoretical: 133 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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