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RS100329 hydrochloride

Name: RS100329 hydrochloride
Brand: TargetMol
SKU: T23253
Price: 493 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23253Cas No. 1215654-26-4

Alias RS-100329 hcl

RS100329 hydrochloride is an antagonist of α1A-adrenergic receptor.

RS100329 hydrochloride

😃Good

Purity: 99.95%

Catalog No. T23253Alias RS-100329 hclCas No. 1215654-26-4

RS100329 hydrochloride is an antagonist of α1A-adrenergic receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$106	In Stock	In Stock
25 mg	$232	In Stock	In Stock
50 mg	$345	In Stock	In Stock
100 mg	$493	In Stock	In Stock
500 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	RS100329 hydrochloride is an antagonist of α1A-adrenergic receptor.
In vitro	In intact CHO-K1 cells expressing human cloned alpha1A-, alpha1B- and alpha1D-AR showed nanomolar affinity and significant alpha1A-AR subtype selectivity for RS 100329 hydrochloride (pKi 9.6: 126 and 50 fold selectivity) over the alpha1B- and alpha1D-AR subtypes respectively. Noradrenaline-induced contractions of human lower urinary tract (LUT) tissues or rabbit bladder neck were competitively antagonized by RS 100329 hydrochloride (pA2 9.2 and 9.2)[1].
Synonyms	RS-100329 hcl

Chemical Properties

Molecular Weight	462.89
Formula	C₂₀H₂₆ClF₃N₄O₃
Cas No.	1215654-26-4
Smiles	Cl.Cc1c[nH]c(=O)n(CCCN2CCN(CC2)c2ccccc2OCC(F)(F)F)c1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (86.41 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1603 mL	10.8017 mL	21.6034 mL	108.0170 mL
5 mM	0.4321 mL	2.1603 mL	4.3207 mL	21.6034 mL
10 mM	0.2160 mL	1.0802 mL	2.1603 mL	10.8017 mL
20 mM	0.1080 mL	0.5401 mL	1.0802 mL	5.4009 mL
50 mM	0.0432 mL	0.2160 mL	0.4321 mL	2.1603 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc