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TAK-901 hydrochloride
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Catalog No. T88283Cas No. 934542-50-4
TAK-901 hydrochloride functions as a multi-targeted inhibitor of aurora kinases, demonstrating IC50 values of 21 nM for aurora A and 15 nM for aurora B.
TAK-901 hydrochloride
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Catalog No. T88283Cas No. 934542-50-4
TAK-901 hydrochloride functions as a multi-targeted inhibitor of aurora kinases, demonstrating IC50 values of 21 nM for aurora A and 15 nM for aurora B.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,970 | 10-14 weeks | 10-14 weeks | |
| 50 mg | $2,580 | 10-14 weeks | 10-14 weeks | |
| 100 mg | $3,400 | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
Storage & Solubility Information
| Description | TAK-901 hydrochloride functions as a multi-targeted inhibitor of aurora kinases, demonstrating IC50 values of 21 nM for aurora A and 15 nM for aurora B. |
| Targets&IC50 | Aurora B:15 nM, Aurora A:21 nM |
| In vitro | TAK-901 shows a time-dependent, tight-binding inhibitory effect on Aurora B, but this effect is not observed for Aurora A [1]. In PC3 cells, TAK-901 inhibits the phosphorylation of histone H3 in a dose-dependent manner, with an EC50 value of 0.16 μM [1]. TAK-901 is a substrate of the P-glycoprotein (PgP) drug efflux pump, as demonstrated by a decrease in EC50 from 38 nM in uterine sarcoma MES-SA cells to over 50 μM in drug-resistant MES-SA/Dx5 cells with high PgP expression [1]. |
| In vivo | TAK-901 effectively inhibits tumor growth at doses of 30 mg/kg and 40 mg/kg per injection in the A2780 and AML MV4-11 xenograft models in nude mice [1]. |
| Molecular Weight | 541.10 |
| Formula | C28H33ClN4O3S |
| Cas No. | 934542-50-4 |
| Smiles | Cl.O=C(NC1CCN(C)CC1)C=2C=C(C=3C=CC=C(C3)S(=O)(=O)CC)C=4C5=CC(=CN=C5NC4C2C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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