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gamma-Secretase Modulators

Name: gamma-Secretase Modulators
Brand: TargetMol
SKU: T11362
Rating: 4.5 (1 reviews)

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Catalog No. T11362Cas No. 937812-80-1

Alias γ-Secretase Modulators, Amyloid-β production inhibitor

gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.

gamma-Secretase Modulators

😃Good

Catalog No. T11362Alias γ-Secretase Modulators, Amyloid-β production inhibitorCas No. 937812-80-1

gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.

Pack Size	Price	Availability
25 mg	$3,870	3-6 months
50 mg	$4,880	3-6 months
100 mg	$6,500	3-6 months

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
Synonyms	γ-Secretase Modulators, Amyloid-β production inhibitor

Chemical Properties

Molecular Weight	483.48
Formula	C₂₆H₂₄F₃N₃O₃
Cas No.	937812-80-1
Relative Density.	1.37g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (206.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0683 mL	10.3417 mL	20.6834 mL	103.4169 mL
5 mM	0.4137 mL	2.0683 mL	4.1367 mL	20.6834 mL
10 mM	0.2068 mL	1.0342 mL	2.0683 mL	10.3417 mL
20 mM	0.1034 mL	0.5171 mL	1.0342 mL	5.1708 mL
50 mM	0.0414 mL	0.2068 mL	0.4137 mL	2.0683 mL
100 mM	0.0207 mL	0.1034 mL	0.2068 mL	1.0342 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc