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B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)
(Synonyms: LICOS, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP1B7-like protein Gl50, B7RP-1, B7RP1, B7-H2B7-related protein 1, B7-H2, B7H2) Copy Product InfoSynonyms: LICOS, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP1B7-like protein Gl50, B7RP-1, B7RP1, B7-H2B7-related protein 1, B7-H2, B7H2
Catalog No. TMPK-00192 Copy Product Info
B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.5 kDa and the accession number is O75144.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $35 | 7-10 days | 7-10 days | |
| 10 μg | $52 | 7-10 days | 7-10 days | |
| 20 μg | $81 | 7-10 days | 7-10 days | |
| 50 μg | $153 | 7-10 days | 7-10 days | |
| 100 μg | $255 | 7-10 days | 7-10 days | |
| 200 μg | $459 | 7-10 days | 7-10 days | |
| 500 μg | $1,020 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1. Immobilized Human B7-H2, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Human ICOS, hFc Tag with the EC50 of 23.6ng/ml determined by ELISA.
2. Human ICOS, hFc Tag (Q50A) captured on CM5 Chip via Protein A can bind Human B7-H2, His Tag with an affinity constant of 41.98 nM as determined in SPR assay. |
| Description | B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.5 kDa and the accession number is O75144. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His-Avi |
| Accession Number | O75144 |
| Construction | Asp19-Ser258 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | LICOS, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP1B7-like protein Gl50, B7RP-1, B7RP1, B7-H2B7-related protein 1, B7-H2, B7H2 |
| Research Background |
| Molecular Weight | 29.5 kDa (predicted). Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result. |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) chemical structure | B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) molecular weight
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