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CGP 37849

Name: CGP 37849
Brand: TargetMol
SKU: T7720
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7720Cas No. 127910-31-0

Alias CGP-37849, CGP37849

CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents and also has antidepressant and anxiolytic properties.

CGP 37849

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Purity: 99.86%

Catalog No. T7720Alias CGP-37849, CGP37849Cas No. 127910-31-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$129	In Stock	In Stock
2 mg	$183	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$455	-	In Stock
25 mg	$719	-	In Stock
50 mg	$948	-	In Stock
100 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$296	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents and also has antidepressant and anxiolytic properties.
Targets&IC50	Seizures:21 mg/kg(ED50), l-[3H]-glutamate:220 nM(Ki), [3H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP):35 nM(Ki)
In vitro	Within the hippocampal slice in vitro, CGP 37849 demonstrates reversible and selective antagonism against NMDA-induced increases in the firing rate of CA1 pyramidal cells. In the presence of a low Mg2+ level medium, concentrations of CGP 37849 up to 10 μM effectively inhibit burst firing evoked in CA1 neurons by stimulating Schaffer collateral-commissural fibers, while leaving the magnitude of the initial population spike unaffected.[1]
In vivo	In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurons induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate.[1] Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an ED50 of 21 mg/kg.[1]
Synonyms	CGP-37849, CGP37849

Chemical Properties

Molecular Weight	209.14
Formula	C₆H₁₂NO₅P
Cas No.	127910-31-0
Smiles	C\C(CP(O)(O)=O)=C/C(N)C(O)=O
Relative Density.	1.506 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 90 mg/mL (430.33 mM), Sonication is recommended.

DMSO: Soluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.7815 mL	23.9074 mL	47.8149 mL	239.0743 mL
5 mM	0.9563 mL	4.7815 mL	9.5630 mL	47.8149 mL
10 mM	0.4781 mL	2.3907 mL	4.7815 mL	23.9074 mL
20 mM	0.2391 mL	1.1954 mL	2.3907 mL	11.9537 mL
50 mM	0.0956 mL	0.4781 mL	0.9563 mL	4.7815 mL
100 mM	0.0478 mL	0.2391 mL	0.4781 mL	2.3907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc