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Monensin sodium salt

(Synonyms: Sodium Monensin, Monensin A sodium salt) Copy Product Info
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Synonyms: Sodium Monensin, Monensin A sodium salt

Catalog No. T1033 Copy Product Info
Purity: 98.9%
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Monensin sodium salt (Monensin A sodium salt) is an antibiotic secreted by Streptomyces cinnamaticus and acts as an ion carrier that mediates Na+/H+ exchange. Monensin is an effective inhibitor of Wnt signaling. Monensin causes a significant increase in multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium salt exhibits biological activities including anticoccidial, antibacterial, antitumor, and cell signaling regulatory effects. Monensin sodium salt can be used in studies of cellular ion transport and metabolism.
Monensin sodium salt
Cas No. 22373-78-0
Other Forms of Monensin sodium salt:
Pack SizePriceUSA StockGlobal StockQuantity
50 mg$30In StockIn Stock
100 mg$42In StockIn Stock
200 mg$58In StockIn Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.9%
Color:White
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Product Introduction

Bioactivity
Description
Monensin sodium salt (Monensin A sodium salt) is an antibiotic secreted by Streptomyces cinnamaticus and acts as an ion carrier that mediates Na+/H+ exchange. Monensin is an effective inhibitor of Wnt signaling. Monensin causes a significant increase in multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium salt exhibits biological activities including anticoccidial, antibacterial, antitumor, and cell signaling regulatory effects. Monensin sodium salt can be used in studies of cellular ion transport and metabolism.
In vitro
Methods: Primary and immortalized RPTCs were cultured and treated with 10 μmol/L monensin sodium salt for 24 hours. Changes in NBCe2 protein expression and localization were detected via immunofluorescence and Western blot analysis.
Results: Following monensin sodium salt treatment, NBCe2 expression increased on the cell surface. [1]
Methods: hRPTCs loaded with SBFI (sodium-sensitive fluorescent dye) were treated with 10 μmol/L monensin sodium salt for 30 minutes. Changes in intracellular sodium concentration were monitored in real-time post-treatment.
Results: Monensin sodium salt significantly increased the F340/F380 SBFI fluorescence ratio, demonstrating its ability to effectively elevate intracellular sodium concentration. [1]
In vivo
Methods: Adult male ICR mice were randomly divided into three groups (9 mice per group): Control group: Free access to water for 28 days; Cadmium poisoning group: Cadmium acetate (20 mg/kg body weight) administered orally daily for the first 14 days, followed by free access to water for the subsequent 14 days; Monensin treatment group: Same cadmium exposure as above for the first 14 days, followed by daily oral administration of monensin tetrahydrate (16 mg/kg body weight) for the subsequent 14 days. From day 15 to day 28, monensin sodium salt (16 mg/kg) was administered orally for 14 consecutive days.
Results: Monensin sodium salt treatment significantly reduced hepatic cadmium concentration by approximately 50% and restored cadmium-disturbed hepatic copper and zinc levels. [2]
SynonymsSodium Monensin, Monensin A sodium salt
Chemical Properties
Molecular Weight692.85
FormulaC36H61NaO11
Cas No.22373-78-0
Smiles[Na+].CC[C@]1(CC[C@@H](O1)[C@]1(C)CC[C@]2(C[C@H](O)[C@@H](C)[C@H](O2)[C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O1)[C@@H]1O[C@H](C[C@@H]1C)[C@H]1O[C@@](O)(CO)[C@H](C)C[C@@H]1C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 12.5 mg/mL (18.04 mM), Sonication is recommended.
DMSO: < 1 mg/mL (insoluble or slightly soluble)
In Vivo Formulation
10% EtOH+90% Corn Oil: 1 mg/mL (1.44 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol
1mg5mg10mg50mg
1 mM1.4433 mL7.2166 mL14.4331 mL72.1657 mL
5 mM0.2887 mL1.4433 mL2.8866 mL14.4331 mL
10 mM0.1443 mL0.7217 mL1.4433 mL7.2166 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

Sodium-hydrogen ExchangerSodiumChannelSodium/hydrogen ExchangerSodium ChannelNa+/H+ Exchanger (NHE)Monensin sodium saltMonensin sodiumMonensin A sodiumMonensin AMonensinInhibitorinhibitBacterialAntibioticAntibacterial
Related Tags: Monensin sodium salt chemical structure | Monensin sodium salt in vivo | Monensin sodium salt in vitro | Monensin sodium salt formula | Monensin sodium salt molecular weight
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