PROTAC TTK degrader-1

Name: PROTAC TTK degrader-1
Brand: TargetMol
SKU: T81375
Rating: 4.5 (1 reviews)

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Catalog No. T81375Cas No. 2953426-43-0

PROTAC TTK degrader-1, a potent threonine tyrosine kinase (TTK) PROTAC degrader, demonstrates DC50 values of 1.7 nM in COLO-205 cells and 5.8 nM in HCT-116 cells, indicating effective target degradation. Furthermore, it shows anticancer efficacy in a xenograft mouse model with COLO-205 human colorectal cancer cells [1].

PROTAC TTK degrader-1

😃Good

Catalog No. T81375Cas No. 2953426-43-0

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Product Introduction

Bioactivity

Description	PROTAC TTK degrader-1, a potent threonine tyrosine kinase (TTK) PROTAC degrader, demonstrates DC50 values of 1.7 nM in COLO-205 cells and 5.8 nM in HCT-116 cells, indicating effective target degradation. Furthermore, it shows anticancer efficacy in a xenograft mouse model with COLO-205 human colorectal cancer cells [1].
In vitro	Compound 8e, a PROTAC TTK degrader-1, demonstrates antiproliferative activity against cancer cells at concentrations ranging from 0 to 10 μM over a 96-hour period [1].
In vivo	PROTAC TTK degrader-1 administered intraperitoneally (IP) at a single dose of 10 mg/kg exhibits satisfactory pharmacokinetic profiles [1]. When administered IP at doses of 10 or 20 mg/kg once daily over a 16-day period, PROTAC TTK degrader-1 substantially decreases TTK protein levels and demonstrates significant tumor growth inhibition [1].

Chemical Properties

Molecular Weight	855.98
Formula	C₄₇H₅₃N₉O₇
Cas No.	2953426-43-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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