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PROTAC TTK degrader-1

Catalog No. T81375 CAS 2953426-43-0

PROTAC TTK degrader-1, a potent threonine tyrosine kinase (TTK) PROTAC degrader, demonstrates DC50 values of 1.7 nM in COLO-205 cells and 5.8 nM in HCT-116 cells, indicating effective target degradation. Furthermore, it shows anticancer efficacy in a xenograft mouse model with COLO-205 human colorectal cancer cells [1].

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PROTAC TTK degrader-1 Chemical Structure

PROTAC TTK degrader-1, CAS 2953426-43-0

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Description	PROTAC TTK degrader-1, a potent threonine tyrosine kinase (TTK) PROTAC degrader, demonstrates DC50 values of 1.7 nM in COLO-205 cells and 5.8 nM in HCT-116 cells, indicating effective target degradation. Furthermore, it shows anticancer efficacy in a xenograft mouse model with COLO-205 human colorectal cancer cells [1].
In vitro	Compound 8e, a PROTAC TTK degrader-1, demonstrates antiproliferative activity against cancer cells at concentrations ranging from 0 to 10 μM over a 96-hour period [1].
In vivo	PROTAC TTK degrader-1 administered intraperitoneally (IP) at a single dose of 10 mg/kg exhibits satisfactory pharmacokinetic profiles [1]. When administered IP at doses of 10 or 20 mg/kg once daily over a 16-day period, PROTAC TTK degrader-1 substantially decreases TTK protein levels and demonstrates significant tumor growth inhibition [1].

Molecular Weight	855.98
Formula	C47H53N9O7
CAS No.	2953426-43-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Related Products

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Dovitinib-RIBOTAC PTD10 di-Ellipticine-RIBOTAC PROTAC TG2 degrader-2 PROTAC TG2 degrader-1 Pomalidomid-C6-PEG3-butyl-N3 dBRD9 PROTAC BRD9 Degrader-7

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Keywords

PROTAC TTK degrader-1 2953426-43-0 PROTAC PROTACs inhibitor inhibit

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