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Tacedinaline

Name: Tacedinaline
Brand: TargetMol
SKU: T1888
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1888Cas No. 112522-64-2

Alias PD-123654, N-acetyldinaline, Goe-5549, CI994, Acetyldinaline

Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity.

Tacedinaline

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Purity: 99.15%

Catalog No. T1888Alias PD-123654, N-acetyldinaline, Goe-5549, CI994, AcetyldinalineCas No. 112522-64-2

Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$43	In Stock	In Stock
50 mg	$66	In Stock	In Stock
100 mg	$97	In Stock	In Stock
200 mg	$171	In Stock	In Stock
500 mg	$369	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.15%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity.
Targets&IC50	HDAC1:0.9 μM, HDAC3:1.2 μM, HDAC2:0.9 μM
In vitro	In models of chemotherapy-resistant pancreatic ductal adenocarcinoma in mice and human prostate tumor, CI-994 consistently demonstrated antitumor activity.
In vivo	CI-994 exhibits antitumor activity, displaying enhanced cytocidal effects in solid tumors. It inhibits cell growth across various cell types, including rat leukemia BCLO cells (IC50=2.5 µM) and LNCaP cells (IC50=7.4 µM). In A-549 and LX-1 cells, CI-994 (<160 mM) increases the number of cells in the G0/G1 phase while decreasing those in the S phase, effectively inhibiting cell growth and inducing apoptosis.
Cell Research	LNCaP cell lines are maintained in RPMI 1640 medium containing 10% fetal bovine serum, 1% penicillin and streptomycin, as the complete culture medium. Cells (2×104) are seeded in 24-well plates and incubated in a 5% CO2 incubator at 37 °C for 1 day. Cultures are treated with CI-994, alone and in combination on day 2 and 4. Cells are washed on day 2 and 4 and media are changed. Mitochondrial metabolism is measured as a marker for cell growth by adding 100 μL/well MTT (5 mg/mL in medium) with 2 hours incubation at 37 °C on Day 6. Crystals formed are dissolved in 500 μL of DMSO. The absorbance is determined using a microplate reader at 560 nm. The absorbance data are converted into cell proliferation percentage. Each assay is performed in triplicate. (Only for Reference)
Synonyms	PD-123654, N-acetyldinaline, Goe-5549, CI994, Acetyldinaline

Chemical Properties

Molecular Weight	269.3
Formula	C₁₅H₁₅N₃O₂
Cas No.	112522-64-2
Smiles	N(C(=O)C1=CC=C(NC(C)=O)C=C1)C2=C(N)C=CC=C2
Relative Density.	1.322 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33.33 mg/mL (123.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7133 mL	18.5667 mL	37.1333 mL	185.6665 mL
5 mM	0.7427 mL	3.7133 mL	7.4267 mL	37.1333 mL
10 mM	0.3713 mL	1.8567 mL	3.7133 mL	18.5667 mL
20 mM	0.1857 mL	0.9283 mL	1.8567 mL	9.2833 mL
50 mM	0.0743 mL	0.3713 mL	0.7427 mL	3.7133 mL
100 mM	0.0371 mL	0.1857 mL	0.3713 mL	1.8567 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc