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Cell Cycle/Checkpoint

Nucleoside Antimetabolite/Analog

Poly(ADP-ribose) Glycohydrolase (PARG)

Serine/threonin kinase

(90)

Wee1

(31)

Y Box Binding Protein 1

(4)

c-Myc

(100)

LIM Kinase

The LIM kinase family consists of just two members: LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2). With uniquely organised signalling domains, LIM kinases are regulated by several upstream signalling pathways, principally acting downstream of Rho GTPases to influence the architecture of the actin cytoskeleton by regulating the activity of the cofilin family proteins cofilin1, cofilin2 and destrin. Although the LIM kinases are very homologous, particularly when comparing kinase domains, there is emerging evidence that each may be subject to different regulatory pathways and may contribute to both distinct and overlapping cellular and developmental functions.

Filter HomeSignaling PathwaysCell Cycle/CheckpointLIM Kinase

CRT-0105950

T239171661845-86-8

CRT-0105950 is a potent LIMK inhibitor with high affinity for both LIMK1 and LIMK2.CRT-0105950 inhibits filamentous cutin phosphorylation and promotes α-microtubulin acetylation in cells.CRT-0105950 can be used in the study of renal carcinoma.

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RSS0680

T746432769753-48-0

RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.

$399

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BMS-3

T46001338247-30-5

BMS-3 is a potent LIMK inhibitor with IC50 values of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.

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BMS-5

T45981338247-35-0

BMS-5 (LIMKi 3) is a highly potent LIMK inhibitor, exhibiting IC50 values of 7 nM for LIMK1 and 8 nM for LIMK2.

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Cited

LX7101

T157981192189-69-7In house

LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).

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T56-LIMKi

T3960924473-59-6

T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.

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TH-257

T71282244678-29-1

TH-257 is a Potent and selective allosteric LIMK 1 2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).

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limk-in-22j

T244101116571-01-7

LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.

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SM1-71

T366802088179-99-9

SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1 2 3 4 6 7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A B, MAPK1 3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines.

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LX-7101 hydrochloride

T329851374644-80-0In house

LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1 2, ROCK, PKA, and can be used to study glaucoma.

$195

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R-10015

T126092097938-51-5

R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 nM. It also exerts broad-spectrum antiviral effects and may be used in HIV infection research.

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Damnacanthal

TN1549477-84-9

Damnacanthal is a natural anthraquinone compound with potential anticancer, anti-inflammatory, antioxidant, anti-malarial, and antiviral effects.Damnacanthal inhibits a variety of protein kinases such as LIMK1 (IC50=0.8 μM), LIMK2 (IC50=1.5 μM), and Lck (IC50=17 nM), and inhibits the growth of human hepatocellular carcinoma (SKHep-1) and human breast cancer (MCF-7) cells.

$800

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DB1113

T746422769753-53-7

DB1113 (Example 24) is a bifunctional compound designed for the targeted degradation of various kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. This capability positions DB1113 as a valuable tool for research into diseases or disorders associated with aberrant kinase activity [1].

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S3 Fragment

T80253

S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF cofilin, which is the target of LIM kinase (LIMK) phosphorylation. LIMK1, a pivotal regulator of the actin cytoskeleton, phosphorylates ADF cofilin at serine-3, leading to its inactivation. As a segment of the S3 peptide harboring the serine-3 sequence, this fragment serves as a widely recognized competitive inhibitor of LIMK1.

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LIMK1 inhibitor 1

T204784332904-10-6

LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.

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10-14 weeks

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8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide

T75556956707-04-3

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].

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LIMK-IN-2

T868112747216-27-7

LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].

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10-14 weeks

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DB0614

T746442769753-47-9

DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. This compound has potential applications in research on diseases or disorders caused by aberrant kinase activity [1].

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SR7826

T262241219728-20-7

SR7826 is a selective LIMK inhibitor.

$652

6-8 weeks

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Aurora/LIM kinase-IN-1

T60783

Aurora LIM kinase-IN-1 (Compound F114) is a potent dual inhibitor of aurora and LIM kinases. It inhibits the proliferation and invasion of glioblastoma multiforme (GBM), making it a potential candidate for drug development in GBM and other cancers. Aurora and LIM kinases are involved in neoplastic cell division and cell motility, respectively [1].

$1,520

10-14 weeks

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limk1 inhibitor bms-4

T72399905298-84-2

LIMK1 inhibitor BMS-4 is a compound targeting LIM Kinase (LIMK) 1 2, specifically inhibiting the phosphorylation of its substrate cofilin, while remaining noncytotoxic on A549 cells.

$1,670

6-8 weeks

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Curcolonol

TN3731217817-09-9

Curcolonol is a natural product of Curcuma, Zingiberaceae. The catalog number is TN3731 and the CAS number is 217817-09-9. Curcolonol can be used as a reference standard.