IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 60.00 | |
50 μg | 5 days | $ 184.00 | |
500 μg | 5 days | $ 1,350.00 | |
1 mg | 5 days | $ 2,010.00 |
Description | IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease. |
Species | Human |
Expression System | Human Cells |
Tag | C-Fc-6His |
Accession Number | O95256 |
Synonyms | IL-1R accessory protein-like, Interleukin-18 receptor β, C, IL18RAP, CD218 antigen-like family member B, Interleukin-1 receptor 7, Accessory protein-like, Interleukin-18 receptor accessory protein, Interleukin-18 receptor accessory protein-like, Interleukin-18 receptor beta, CDw218b |
Amino Acid | Phe20-Arg356 |
Construction | Recombinant Human Interleukin-18 receptor accessory protein is produced by our Mammalian expression system and the target gene encoding Phe20-Arg356 is expressed with a human IgG1 Fc, 6His tag at the C-terminus. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 88 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Research Background | IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease. |
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IL-18RAP Protein, Human, Recombinant (hFc & His) IL-1R accessory protein-like Interleukin-18 receptor β C IL18RAP CD218 antigen-like family member B Interleukin-1 receptor 7 Accessory protein-like Interleukin-18 receptor accessory protein Interleukin-18 receptor accessory protein-like Interleukin-18 receptor beta CDw218b recombinant recombinant-proteins proteins protein