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Bezafibrate

Name: Bezafibrate
Brand: TargetMol
SKU: T0841
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0841Cas No. 41859-67-0

Alias BM15075

Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.

Bezafibrate

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Purity: 99.82%

Catalog No. T0841Alias BM15075Cas No. 41859-67-0

Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$36	In Stock	In Stock
100 mg	$50	In Stock	In Stock
200 mg	$63	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
Targets&IC50	PPARγ (human):60 μM, PPARα (human):50 μM, PPARγ (murine):55 μM, PPARδ (human):20 μM, PPARδ (murine):110 μM, PPARα (murine):90 μM
In vitro	Bezafibrate significantly decreases plasma triglyceride and leptin levels without altering the expression of PPARγ in white adipose tissue or the ob gene. Treatment with Bezafibrate resulted in much smaller gonadal fat stores in wild-type and PPARβ-null mice (2.8 and ~2.6 times less, respectively) than in controls, while PPARα-null mice did not exhibit this effect. Bezafibrate altered the expression of mRNAs coding for lipid metabolism enzymes, such as AOX, CYP4A, LPL, ACS, and LCAD, in wild-type, PPARβ-null, and PPARα-null mice. It induced the expression of UCPs in rat epididymal white adipose tissue and altered energy balance by directly inducing aco gene expression (14.5-fold increase on day 7) and peroxisomal fatty acid beta-oxidation. Bezafibrate treatment upregulated mRNA levels of M-CPT-I (4.5-fold), fatty acid translocase (2.6-fold), and Pref-1 (5.6-fold) in rat epididymal white adipose tissue. Compared to controls, Bezafibrate significantly increased liver weight in wild-type and PPARβ-null mice, with no change observed in PPARα-null mice.
In vivo	Bezafibrate exhibits an EC50 of 5 μM when binding to xPPARβ. Additionally, Bezafibrate activates the transcription of Xenopus PPARβ with an EC50 of 1 μM.
Synonyms	BM15075

Chemical Properties

Molecular Weight	361.82
Formula	C₁₉H₂₀ClNO₄
Cas No.	41859-67-0
Smiles	C(NCCC1=CC=C(OC(C(O)=O)(C)C)C=C1)(=O)C2=CC=C(Cl)C=C2
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 15 mg/mL (41.46 mM), Sonication is recommended.

DMSO: 260 mg/mL (718.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7638 mL	13.8190 mL	27.6381 mL	138.1903 mL
5 mM	0.5528 mL	2.7638 mL	5.5276 mL	27.6381 mL
10 mM	0.2764 mL	1.3819 mL	2.7638 mL	13.8190 mL
20 mM	0.1382 mL	0.6910 mL	1.3819 mL	6.9095 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0553 mL	0.2764 mL	0.5528 mL	2.7638 mL
100 mM	0.0276 mL	0.1382 mL	0.2764 mL	1.3819 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc