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Phenylbiguanide

Name: Phenylbiguanide
Brand: TargetMol
SKU: T7135
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7135Cas No. 102-02-3

Alias PBG, N-Phenylbiguanide, 1-Phenylbiguanide

Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)

Phenylbiguanide

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Purity: 99.54%

Catalog No. T7135Alias PBG, N-Phenylbiguanide, 1-PhenylbiguanideCas No. 102-02-3

Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$33	In Stock	In Stock
500 mg	$53	-	In Stock
1 g	$77	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.54%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)
Targets&IC50	5-HT3:3 μM (EC50)
In vivo	Phenylbiguanide (PBG) is a drug known to stimulate cardiopulmonary afferent C-fibres. PBG is injected into the right atrium of the heart in anaesthetised mice and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression[1].
Synonyms	PBG, N-Phenylbiguanide, 1-Phenylbiguanide

Chemical Properties

Molecular Weight	177.21
Formula	C₈H₁₁N₅
Cas No.	102-02-3
Smiles	N(C(NC(=N)N)=N)C1=CC=CC=C1
Relative Density.	1.2512 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (846.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (22.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6430 mL	28.2151 mL	56.4302 mL	282.1511 mL
5 mM	1.1286 mL	5.6430 mL	11.2860 mL	56.4302 mL
10 mM	0.5643 mL	2.8215 mL	5.6430 mL	28.2151 mL
20 mM	0.2822 mL	1.4108 mL	2.8215 mL	14.1076 mL
50 mM	0.1129 mL	0.5643 mL	1.1286 mL	5.6430 mL
100 mM	0.0564 mL	0.2822 mL	0.5643 mL	2.8215 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc