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Phenylbiguanide

Name: Phenylbiguanide
Brand: TargetMol
SKU: T7135
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7135Cas No. 102-02-3

Alias PBG, N-Phenylbiguanide, 1-Phenylbiguanide

Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)

Phenylbiguanide

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Purity: 99.54%

Catalog No. T7135Alias PBG, N-Phenylbiguanide, 1-PhenylbiguanideCas No. 102-02-3

Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$32	-	In Stock
1 g	$46	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.54%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM)
Targets&IC50	5-HT3:3 μM (EC50)
In vivo	Phenylbiguanide (PBG) is a drug known to stimulate cardiopulmonary afferent C-fibres. PBG is injected into the right atrium of the heart in anaesthetised mice and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression[1].
Synonyms	PBG, N-Phenylbiguanide, 1-Phenylbiguanide

Chemical Properties

Molecular Weight	177.21
Formula	C₈H₁₁N₅
Cas No.	102-02-3
Smiles	N(C(NC(=N)N)=N)C1=CC=CC=C1
Relative Density.	1.2512 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (846.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (22.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6430 mL	28.2151 mL	56.4302 mL	282.1511 mL
5 mM	1.1286 mL	5.6430 mL	11.2860 mL	56.4302 mL
10 mM	0.5643 mL	2.8215 mL	5.6430 mL	28.2151 mL
20 mM	0.2822 mL	1.4108 mL	2.8215 mL	14.1076 mL
50 mM	0.1129 mL	0.5643 mL	1.1286 mL	5.6430 mL
100 mM	0.0564 mL	0.2822 mL	0.5643 mL	2.8215 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc