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Avibactam free acid

Name: Avibactam free acid
Brand: TargetMol
SKU: T10422
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10422Cas No. 1192500-31-4

Alias NXL104 free acid

Avibactam free acid is a potent β-lactamase inhibitor exhibiting covalent and reversible properties, capable of inhibiting TEM-1, P99, and CTX-M-15 at nanomolar concentrations. Avibactam free acid and Ceftazidime may be combined for treating urinary tract infections.

Avibactam free acid

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Purity: 99.17%

Catalog No. T10422Alias NXL104 free acidCas No. 1192500-31-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$36	-	In Stock
5 mg	$58	-	In Stock
10 mg	$78	-	In Stock
25 mg	$98	-	In Stock
50 mg	$127	-	In Stock
100 mg	$187	-	In Stock
1 mL x 10 mM (in DMSO)	$64	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.17%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Avibactam free acid is a potent β-lactamase inhibitor exhibiting covalent and reversible properties, capable of inhibiting TEM-1, P99, and CTX-M-15 at nanomolar concentrations. Avibactam free acid and Ceftazidime may be combined for treating urinary tract infections.
Targets&IC50	TEM1:8 nM, CTX-M-15:5 nM
In vitro	Using TEM-1 as the research subject, the inhibitory effect of Avibactam free acid was characterized by measuring the on-rate (acylation) and off-rate (deacylation) of the enzyme. The results showed that the deacylation dissociation rate was 0.045 min⁻¹, providing potential insights into the deacylation pathway of TEM-1 enzyme. Using nuclear magnetic resonance (NMR) and mass spectrometry (MS), we discovered that the deacylation process regenerates intact Avibactam free acid rather than proceeding via hydrolysis [1].
In vivo	In the mouse model infected with Klebsiella pneumoniae strain Y8, Ceftazidime-Avibactam free acid (0.375 mg/g, subcutaneous injection, every 8 hours for 10 days) exhibited significant antibacterial effects and produced certain therapeutic outcomes [3]. In the neutropenic pneumonia mouse model with Pseudomonas aeruginosa infection, following a single subcutaneous injection of Avibactam free acid (64 mg/kg), the mean estimated terminal-phase half-life in mouse plasma was 0.24 hours [3].
Synonyms	NXL104 free acid

Chemical Properties

Molecular Weight	265.24
Formula	C₇H₁₁N₃O₆S
Cas No.	1192500-31-4
Smiles	[H][C@]12CN([C@@H](CC1)C(N)=O)C(=O)N2OS(O)(=O)=O
Relative Density.	1.85 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (377.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (12.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7702 mL	18.8509 mL	37.7017 mL	188.5085 mL
5 mM	0.7540 mL	3.7702 mL	7.5403 mL	37.7017 mL
10 mM	0.3770 mL	1.8851 mL	3.7702 mL	18.8509 mL
20 mM	0.1885 mL	0.9425 mL	1.8851 mL	9.4254 mL
50 mM	0.0754 mL	0.3770 mL	0.7540 mL	3.7702 mL
100 mM	0.0377 mL	0.1885 mL	0.3770 mL	1.8851 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc