PKM2 Protein, Human, Recombinant (His) V2

Catalog No. TMPY-04465U

PKM2 Protein, Human, Recombinant (His) V2 is expressed in E. coli. The accession number is P14618.

PKM2 Protein, Human, Recombinant (His) V2

Catalog No. TMPY-04465U

PKM2 Protein, Human, Recombinant (His) V2 is expressed in E. coli. The accession number is P14618.

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Product Information

Biological Activity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	PKM2 Protein, Human, Recombinant (His) V2 is expressed in E. coli. The accession number is P14618.
Species	Human
Expression System	E. coli
Tag	N-6xHis
Accession Number	P14618
Synonyms	THBP1,TCB,pyruvate kinase, muscle,PKM2,PK3,OIP3,HEL-S-30,CTHBP
Construction	Ser2-Pro531
Protein Purity	> 95% as determined by SDS-PAGE
Molecular Weight	60.1 kDa (Predicted); 60 kDa (Reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 50 mM NaCl, 0.05% Brij-35, 1mM DTT, pH7.5.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Pyruvate kinase isoform M2 (PKM2) is a member of the pyruvate kinase (PK) family, a pivotal glycolytic enzyme that is consistently changed during tumorigenesis. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets. As the rate-controlling enzyme in glycolysis, PKM2, has also been found to be expressed in embryonic, proliferating, and tumor cells, and it has been considered to be crucial for the metabolism and growth of tumor cells. Recent studies have shown that PKM2 promotes cell proliferation and suppresses cell apoptosis in various tumors. In addition, it has been reported that the PKM2 knockdown affects the Akt and ERK protein kinases.