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ONO 1301

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Catalog No. T28240Cas No. 176391-41-6
Alias ONO-AP 500-02, ONO-1301, ONO1301

ONO 1301 is a prostaglandin I2 mimetic compound with inhibitory activity against thromboxane A2 synthase, and it suppresses pancreatic fibrosis in the DBTC-induced chronic pancreatitis model by inhibiting monocyte activity through both direct effects of ONO 1301 and induction of hepatocyte growth factor. ONO 1301 also promoting HGF synthesis and elevating intracellular cyclic AMP levels via IP-receptor signaling, highlighting its therapeutic relevance in fibrotic disease and inflammation research.

ONO 1301

ONO 1301

😃Good
Catalog No. T28240Alias ONO-AP 500-02, ONO-1301, ONO1301Cas No. 176391-41-6
ONO 1301 is a prostaglandin I2 mimetic compound with inhibitory activity against thromboxane A2 synthase, and it suppresses pancreatic fibrosis in the DBTC-induced chronic pancreatitis model by inhibiting monocyte activity through both direct effects of ONO 1301 and induction of hepatocyte growth factor. ONO 1301 also promoting HGF synthesis and elevating intracellular cyclic AMP levels via IP-receptor signaling, highlighting its therapeutic relevance in fibrotic disease and inflammation research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$686-8 weeks6-8 weeks
5 mg$1636-8 weeks6-8 weeks
10 mg$2896-8 weeks6-8 weeks
25 mg$5956-8 weeks6-8 weeks
50 mg$9876-8 weeks6-8 weeks
100 mg$1,7306-8 weeks6-8 weeks
1 mL x 10 mM (in DMSO)$1796-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
ONO 1301 is a prostaglandin I2 mimetic compound with inhibitory activity against thromboxane A2 synthase, and it suppresses pancreatic fibrosis in the DBTC-induced chronic pancreatitis model by inhibiting monocyte activity through both direct effects of ONO 1301 and induction of hepatocyte growth factor. ONO 1301 also promoting HGF synthesis and elevating intracellular cyclic AMP levels via IP-receptor signaling, highlighting its therapeutic relevance in fibrotic disease and inflammation research.
In vitro
In platelet function assays, ONO 1301 inhibited collagen-induced platelet aggregation in a concentration-dependent manner with an IC50 of 460 nM. Additionally, in primary osteoblasts and ST2 stromal cells, treatment with the compound (0-1000 nM) significantly increased alkaline phosphatase (ALP) activity, serving as a marker for osteoblast differentiation [1].
SynonymsONO-AP 500-02, ONO-1301, ONO1301
Chemical Properties
Molecular Weight428.48
FormulaC26H24N2O4
Cas No.176391-41-6
SmilesC(CO/N=C(\C1=CC=CC=C1)/C=2C=CC=NC2)C=3C=4C(=C(OCC(O)=O)C=CC4)CCC3
Relative Density.1.21 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (93.35 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3338 mL11.6692 mL23.3383 mL116.6916 mL
5 mM0.4668 mL2.3338 mL4.6677 mL23.3383 mL
10 mM0.2334 mL1.1669 mL2.3338 mL11.6692 mL
20 mM0.1167 mL0.5835 mL1.1669 mL5.8346 mL
50 mM0.0467 mL0.2334 mL0.4668 mL2.3338 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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2 Enter the in vivo formulation:
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Ono 1301
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