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ONO 1301

Name: ONO 1301
Brand: TargetMol
SKU: T28240
Rating: 4.5 (1 reviews)

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Catalog No. T28240Cas No. 176391-41-6

Alias ONO-AP 500-02, ONO-1301, ONO1301

ONO 1301 is a prostaglandin I2 mimetic compound with inhibitory activity against thromboxane A2 synthase, and it suppresses pancreatic fibrosis in the DBTC-induced chronic pancreatitis model by inhibiting monocyte activity through both direct effects of ONO 1301 and induction of hepatocyte growth factor. ONO 1301 also promoting HGF synthesis and elevating intracellular cyclic AMP levels via IP-receptor signaling, highlighting its therapeutic relevance in fibrotic disease and inflammation research.

ONO 1301

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Catalog No. T28240Alias ONO-AP 500-02, ONO-1301, ONO1301Cas No. 176391-41-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	6-8 weeks	6-8 weeks
5 mg	$163	6-8 weeks	6-8 weeks
10 mg	$289	6-8 weeks	6-8 weeks
25 mg	$595	6-8 weeks	6-8 weeks
50 mg	$987	6-8 weeks	6-8 weeks
100 mg	$1,730	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$179	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	ONO 1301 is a prostaglandin I2 mimetic compound with inhibitory activity against thromboxane A2 synthase, and it suppresses pancreatic fibrosis in the DBTC-induced chronic pancreatitis model by inhibiting monocyte activity through both direct effects of ONO 1301 and induction of hepatocyte growth factor. ONO 1301 also promoting HGF synthesis and elevating intracellular cyclic AMP levels via IP-receptor signaling, highlighting its therapeutic relevance in fibrotic disease and inflammation research.
Targets&IC50	Collagen-induced platelet aggregation:460 nM
In vitro	In platelet function assays, ONO 1301 inhibited collagen-induced platelet aggregation in a concentration-dependent manner with an IC50 of 460 nM. Additionally, in primary osteoblasts and ST2 stromal cells, treatment with the compound (0-1000 nM) significantly increased alkaline phosphatase (ALP) activity, serving as a marker for osteoblast differentiation [1].
Synonyms	ONO-AP 500-02, ONO-1301, ONO1301

Chemical Properties

Molecular Weight	428.48
Formula	C₂₆H₂₄N₂O₄
Cas No.	176391-41-6
Smiles	C(CO/N=C(\C1=CC=CC=C1)/C=2C=CC=NC2)C=3C=4C(=C(OCC(O)=O)C=CC4)CCC3
Relative Density.	1.21 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (93.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3338 mL	11.6692 mL	23.3383 mL	116.6916 mL
5 mM	0.4668 mL	2.3338 mL	4.6677 mL	23.3383 mL
10 mM	0.2334 mL	1.1669 mL	2.3338 mL	11.6692 mL
20 mM	0.1167 mL	0.5835 mL	1.1669 mL	5.8346 mL
50 mM	0.0467 mL	0.2334 mL	0.4668 mL	2.3338 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ono 1301