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Sulbutiamine

Name: Sulbutiamine
Brand: TargetMol
SKU: T5913
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5913Cas No. 3286-46-2

Alias Bisibuthiamine

Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.

Sulbutiamine

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Purity: 99.47%

Catalog No. T5913Alias BisibuthiamineCas No. 3286-46-2

Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.

Pack Size	Price	Availability	Quantity
100 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock

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Batch Information

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Purity:99.47%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Sulbutiamine (Bisibuthiamine) is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death.
In vitro	Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.
Synonyms	Bisibuthiamine

Chemical Properties

Molecular Weight	702.89
Formula	C₃₂H₄₆N₈O₆S₂
Cas No.	3286-46-2
Smiles	CC(C)C(=O)OCC\C(SS\C(CCOC(=O)C(C)C)=C(/C)N(CC1=C(N)N=C(C)N=C1)C=O)=C(\C)N(CC1=C(N)N=C(C)N=C1)C=O
Relative Density.	1.268g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (56.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4227 mL	7.1135 mL	14.2270 mL	71.1349 mL
5 mM	0.2845 mL	1.4227 mL	2.8454 mL	14.2270 mL
10 mM	0.1423 mL	0.7113 mL	1.4227 mL	7.1135 mL
20 mM	0.0711 mL	0.3557 mL	0.7113 mL	3.5567 mL
50 mM	0.0285 mL	0.1423 mL	0.2845 mL	1.4227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc