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SCH900776 (S-isomer)

Name: SCH900776 (S-isomer)
Brand: TargetMol
SKU: T3700
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3700Cas No. 891494-64-7

Alias SCH900776 S-isomer, MK-8776 S-isomer

SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM).

SCH900776 (S-isomer)

😃Good

Purity: 99.88%

Catalog No. T3700Alias SCH900776 S-isomer, MK-8776 S-isomerCas No. 891494-64-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
2 mg	$64	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$157	In Stock	In Stock
25 mg	$278	-	In Stock
50 mg	$447	Inquiry	Inquiry
100 mg	$659	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM).
Targets&IC50	CDK2:160 nM, Chk2:1500 nM, Chk1:3 nM
In vitro	SCH 900776 does not significantly inhibit HLMs CYP450 isoforms 1A2, 2C9, 2C19, 2D6, and 3A4. SCH 900776 induces a dose-dependent loss of DNA replication capability 24 hours after hydroxyurea exposure. In combination with an antimetabolite, SCH 900776 induces accumulation of γ-H2AX within 2 hours, indicative of replication fork collapse and double-stranded DNA breaks. SCH 900776 also dose-dependently suppresses accumulation of the Chk1 pS296 autophosphorylation.
In vivo	After pretreatment 30 minutes with gemcitabine, SCH 900776 (4 mg/kg) is sufficient to induce the γ-H2AX biomarker while 8 mg/kg leads to enhanced tumor pharmacodynamic and regression responses relative to gemcitabine or SCH 900776 alone. SCH 900776 (16/32 mg/kg) dose-dependently induces improvements in tumor response. Doses of SCH 900776 associate with robust biomarker activation and improved tumor response are not associated with enhanced toxicity of gemcitabine on hematological parameters in BALB/c mice.
Synonyms	SCH900776 S-isomer, MK-8776 S-isomer

Chemical Properties

Molecular Weight	376.25
Formula	C₁₅H₁₈BrN₇
Cas No.	891494-64-7
Smiles	Cn1cc(cn1)-c1cnn2c(N)c(Br)c(nc12)[C@H]1CCCNC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (265.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6578 mL	13.2890 mL	26.5781 mL	132.8904 mL
5 mM	0.5316 mL	2.6578 mL	5.3156 mL	26.5781 mL
10 mM	0.2658 mL	1.3289 mL	2.6578 mL	13.2890 mL
20 mM	0.1329 mL	0.6645 mL	1.3289 mL	6.6445 mL
50 mM	0.0532 mL	0.2658 mL	0.5316 mL	2.6578 mL
100 mM	0.0266 mL	0.1329 mL	0.2658 mL	1.3289 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc