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SCH900776 (S-isomer)

Name: SCH900776 (S-isomer)
Brand: TargetMol
SKU: T3700
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3700Cas No. 891494-64-7

Alias SCH900776 S-isomer, MK-8776 S-isomer

SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM).

SCH900776 (S-isomer)

😃Good

Purity: 99.88%

Catalog No. T3700Alias SCH900776 S-isomer, MK-8776 S-isomerCas No. 891494-64-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
2 mg	$64	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$157	In Stock	In Stock
25 mg	$278	-	In Stock
50 mg	$447	Backorder	Backorder
100 mg	$659	Backorder	Backorder
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.88%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM).
Targets&IC50	CDK2:160 nM, Chk2:1500 nM, Chk1:3 nM
In vitro	SCH 900776 does not significantly inhibit HLMs CYP450 isoforms 1A2, 2C9, 2C19, 2D6, and 3A4. SCH 900776 induces a dose-dependent loss of DNA replication capability 24 hours after hydroxyurea exposure. In combination with an antimetabolite, SCH 900776 induces accumulation of γ-H2AX within 2 hours, indicative of replication fork collapse and double-stranded DNA breaks. SCH 900776 also dose-dependently suppresses accumulation of the Chk1 pS296 autophosphorylation.
In vivo	After pretreatment 30 minutes with gemcitabine, SCH 900776 (4 mg/kg) is sufficient to induce the γ-H2AX biomarker while 8 mg/kg leads to enhanced tumor pharmacodynamic and regression responses relative to gemcitabine or SCH 900776 alone. SCH 900776 (16/32 mg/kg) dose-dependently induces improvements in tumor response. Doses of SCH 900776 associate with robust biomarker activation and improved tumor response are not associated with enhanced toxicity of gemcitabine on hematological parameters in BALB/c mice.
Synonyms	SCH900776 S-isomer, MK-8776 S-isomer

Chemical Properties

Molecular Weight	376.25
Formula	C₁₅H₁₈BrN₇
Cas No.	891494-64-7
Smiles	Cn1cc(cn1)-c1cnn2c(N)c(Br)c(nc12)[C@H]1CCCNC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (265.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6578 mL	13.2890 mL	26.5781 mL	132.8904 mL
5 mM	0.5316 mL	2.6578 mL	5.3156 mL	26.5781 mL
10 mM	0.2658 mL	1.3289 mL	2.6578 mL	13.2890 mL
20 mM	0.1329 mL	0.6645 mL	1.3289 mL	6.6445 mL
50 mM	0.0532 mL	0.2658 mL	0.5316 mL	2.6578 mL
100 mM	0.0266 mL	0.1329 mL	0.2658 mL	1.3289 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc