p53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), the Guardian of the Genome, phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, and thus functions as a tumor suppressor. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.

Cat. No.	Product name	CAS No.	Purity
TN4213	Hirsutenone	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN1354	Aaptamine	85547-22-4	98%
TN1354	Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one	19254-69-4	98%
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
TN1379	Alphitolic acid	19533-92-7	98%
TN1379	Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
T37562	C16 Ceramide	24696-26-2	98%
T37562	C16 Ceramide is a natural small molecule activating p53 through the direct and selective binding.
TN2123	Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside	53171-28-1	98%
TN2123	Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
TN4250	Imbricatolic acid	6832-60-6	98%
TN4250	Imbricatolic acid can prevent cell cycle progression in p53-null CaLu-6 cells.
T67698	WAY-300374	350678-63-6	98%
T67698	WAY-300374 inhibits the p53-MDM2 protein-protein interaction.
TN1688	Ginsenoside Rs3	194861-70-6	98%
TN1688	Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.
T15016	CTX1	501935-96-2	98%
T15016	CTX1 is a small molecule activator of p53.
TN1875	Liriodenine	475-75-2	98%
TN1875	Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
TN3724	Cryptomoscatone D2	276856-55-4	98%
TN3724	Cryptomoscatone D2 is a highly efficacious inhibitor of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage ...
T16771	RO-5963	1416663-77-8	98%
T16771	RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
TN3152	6-Acetonyldihydrochelerythrine	22864-92-2	98%
TN3152	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN2114	Pseudoginsenoside Rh2	1370264-16-6	98%
TN2114	Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
TN3719	Cristacarpin	74515-47-2	98%
TN3719	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
TN3404	Altholactone	65408-91-5	98%
TN3404	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one	569-83-5	98%
TN5263	Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
TN4107	Ganoderic acid X	86377-53-9	98%
TN4107	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN5050	Sprengerinin C	88861-91-0	98%
TN5050	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...