TN4213 |
Hirsutenone
|
41137-87-5
|
98%
|
|
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
|
TN1354 |
Aaptamine
|
85547-22-4
|
98%
|
|
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
|
TN1617 |
Ergosta-4,6,8(14),22-tetraen-3-one
|
19254-69-4
|
98%
|
|
Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
|
TN1379 |
Alphitolic acid
|
19533-92-7
|
98%
|
|
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotox...
|
T37562 |
C16 Ceramide
|
24696-26-2
|
98%
|
|
C16 Ceramide is a natural small molecule activating p53 through the direct and selective binding.
|
TN2123 |
Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
|
53171-28-1
|
98%
|
|
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
|
TN4250 |
Imbricatolic acid
|
6832-60-6
|
98%
|
|
Imbricatolic acid can prevent cell cycle progression in p53-null CaLu-6 cells.
|
T67698 |
WAY-300374
|
350678-63-6
|
98%
|
|
WAY-300374 inhibits the p53-MDM2 protein-protein interaction.
|
TN1688 |
Ginsenoside Rs3
|
194861-70-6
|
98%
|
|
Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.
|
T15016 |
CTX1
|
501935-96-2
|
98%
|
|
CTX1 is a small molecule activator of p53.
|
TN1875 |
Liriodenine
|
475-75-2
|
98%
|
|
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
|
TN3724 |
Cryptomoscatone D2
|
276856-55-4
|
98%
|
|
Cryptomoscatone D2 is a highly efficacious inhibitor of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage ...
|
T16771 |
RO-5963
|
1416663-77-8
|
98%
|
|
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
|
TN3152 |
6-Acetonyldihydrochelerythrine
|
22864-92-2
|
98%
|
|
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
|
TN2114 |
Pseudoginsenoside Rh2
|
1370264-16-6
|
98%
|
|
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
|
TN3719 |
Cristacarpin
|
74515-47-2
|
98%
|
|
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
|
TN3404 |
Altholactone
|
65408-91-5
|
98%
|
|
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
|
TN5263 |
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
|
569-83-5
|
98%
|
|
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
|
TN4107 |
Ganoderic acid X
|
86377-53-9
|
98%
|
|
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
|
TN5050 |
Sprengerinin C
|
88861-91-0
|
98%
|
|
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
|