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Anti-Syntrophin-1+2+3 Polyclonal Antibody
Catalog No. TMAB-13342 Copy Product Info
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Anti-Syntrophin-1+2+3 Polyclonal Antibody is a Rabbit antibody targeting Syntrophin-1+2+3. Anti-Syntrophin-1+2+3 Polyclonal Antibody can be used in WB.
Anti-Syntrophin-1+2+3 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-13342
Anti-Syntrophin-1+2+3 Polyclonal Antibody is a Rabbit antibody targeting Syntrophin-1+2+3. Anti-Syntrophin-1+2+3 Polyclonal Antibody can be used in WB.
Anti-Syntrophin-1+2+3 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Antigen Details
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| Description | Anti-Syntrophin-1+2+3 Polyclonal Antibody is a Rabbit antibody targeting Syntrophin-1+2+3. Anti-Syntrophin-1+2+3 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) |
| Verified Activity | Sample: Lane 1: Mouse Heart tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Mouse Muscle tissue lysates Lane 4: Rat Cerebrum tissue lysates Lane 5: Rat Muscle tissue lysates Primary: Anti-Syntrophin-1+2+3 (TMAB-13342) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kDa Observed band size: 56 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction. Cytoplasm, cytoskeleton. Note=Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction. In insulinoma cell line, it is enriched in secretory granules. |
| Tissue Specificity | Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]. |
| Immunogen | KLH conjugated synthetic peptide: human Syntrophin-1+2+3 |
| Antigen Species | Human |
| Gene Name | SNTA1 |
| Gene ID | |
| Protein Name | alpha-1-syntrophin |
| Uniprot ID | |
| Function | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. |
| Molecular Weight | Theoretical: 59 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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