Shopping Cart

Your shopping cart is currently empty

AZ-1355

Name: AZ-1355
Brand: TargetMol
SKU: T13563
Price: 75 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T13563Cas No. 75451-07-9

AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.

AZ-1355

😃Good

Purity: 99.81%

Catalog No. T13563Cas No. 75451-07-9

AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$75	In Stock	In Stock
5 mg	$183	In Stock	In Stock
10 mg	$248	In Stock	In Stock
25 mg	$375	In Stock	In Stock
50 mg	$512	In Stock	In Stock
100 mg	$667	-	In Stock
200 mg	$910	-	In Stock
1 mL x 10 mM (in DMSO)	$167	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.81%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.
In vivo	AZ-1355 consistently decreases serum total cholesterol (TC) in Triton-induced hyperlipidemic mice at a dose of 150 mg/kg. At a lower dose of 50 mg/kg, it significantly lowers serum triglycerides (TG), while a 100 mg/kg dose effectively reduces both serum TC and TG in rats. Additionally, the 100 mg/kg dosage diminishes total liver TC in rats consuming a CE-2 diet, and a 50 mg/kg dose not only reduces liver TC in rats on a high-fat diet but also decreases total hepatic TG in CE-2 fed rats[1].
Cell Research	The lipid-lowering profile in rodents AZ-1355, A New Dibenzoxazepine Derivative
Animal Research	AZ-1355 (150 mg/kg) reproducibly lowers serum total cholesterol (TC) in the Triton hyperlipidemic mice. AZ-1355 (50 mg/kg) significantly reduces serum TG and the 100 mg/kg dose results in serum TC and TG reduction in rats. AZ-1355 (100 mg/kg) reduces total liver TC in rats fed CE-2, and the 50 mg/kg dose reduces hepatic TC in rats fed the high-fat diet on both bases, and it also reduces the total hepatic TG of the CE-2 fed rats.

Chemical Properties

Molecular Weight	299.32
Formula	C₁₇H₁₇NO₄
Cas No.	75451-07-9
Smiles	O(C)C1=C2C(CNC=3C(O2)=CC=C(C(OCC)=O)C3)=CC=C1
Relative Density.	1.2g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (75.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3409 mL	16.7045 mL	33.4091 mL	167.0453 mL
5 mM	0.6682 mL	3.3409 mL	6.6818 mL	33.4091 mL
10 mM	0.3341 mL	1.6705 mL	3.3409 mL	16.7045 mL
20 mM	0.1670 mL	0.8352 mL	1.6705 mL	8.3523 mL
50 mM	0.0668 mL	0.3341 mL	0.6682 mL	3.3409 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc