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IRAK4-IN-20
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Catalog No. T62714Cas No. 1931994-80-7
Alias BAY-1834845
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).
IRAK4-IN-20
Copy Product Info🥰Excellent
Purity: 98.09%
Catalog No. T62714Alias BAY-1834845Cas No. 1931994-80-7
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $159 | In Stock | In Stock | |
| 5 mg | $413 | In Stock | In Stock | |
| 10 mg | $659 | In Stock | In Stock | |
| 25 mg | $987 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $478 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
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Purity:98.09%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS). |
| Targets&IC50 | IRAK4:3.55 nM |
| In vitro | Compound BAY-1834845 (IRAK4-IN-20) at a concentration of 500 nM, effectively reduces the secretion of inflammatory cytokines when administered for 20 hours in an in vitro assay involving LPS-stimulated human peripheral blood mononuclear cells (PBMC) [1]. |
| In vivo | IRAK4-IN-20 (Compound BAY-1834845), administered orally at 150 mg/kg either once 30 minutes before or twice at 4 and 12 hours after LPS induction, significantly mitigated acute respiratory distress syndrome in 6–7-week-old female Balb/c mice models. This treatment markedly reduced inflammatory cell and neutrophil infiltration in bronchoalveolar lavage fluid (BALF), decreased total T cells, monocytes, and macrophages, and preserved the integrity of naïve lymphocytes and stromal cells, including endothelial cells, chondrocytes, and smooth muscle cells. Moreover, it more effectively regulated inflammation and innate immunity genes compared to Dexamethasone, demonstrating its potential as a therapeutic agent for ARDS. |
| Synonyms | BAY-1834845 |
| Molecular Weight | 450.45 |
| Formula | C22H25F3N4O3 |
| Cas No. | 1931994-80-7 |
| Smiles | C(C)(C)(O)C1=CC=2C(C=C1NC(=O)C=3N=C(C(F)(F)F)C=CC3)=CN(CCC(C)(C)O)N2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (55.5 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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