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Anti-TRIB3 Antibody (9I365)
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Catalog No. TMAB-13767 Copy Product Info
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Anti-TRIB3 Antibody (9I365) is a Rabbit antibody targeting TRIB3. Anti-TRIB3 Antibody (9I365) can be used in WB,IP.
Anti-TRIB3 Antibody
(9I365)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 µL | $151 | 7-10 days | 7-10 days | |
| 50 µL | $262 | 7-10 days | 7-10 days | |
| 100 µL | $470 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-TRIB3 Antibody (9I365) is a Rabbit antibody targeting TRIB3. Anti-TRIB3 Antibody (9I365) can be used in WB,IP. |
| Ig Type | IgG |
| Clone | 9I365 |
| Reactivity | Human |
| Verified Activity | 25 μg total protein per lane of various lysates (see on figure) probed with TRIB3 monoclonal antibody, unconjugated (TMAB-13767) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IP: 1:20-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress.Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. |
| Immunogen | A synthesized peptide: human TRIB3 |
| Antigen Species | Human |
| Gene Name | TRIB3 |
| Gene ID | |
| Protein Name | Tribbles homolog 3 |
| Uniprot ID | |
| Function | Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. |
| Molecular Weight | Theoretical: 40 kDa. Actual: 40 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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