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Anti-TRIB3 Antibody (9I365)

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Catalog No. TMAB-13767

Anti-TRIB3 Antibody (9I365) is a Rabbit antibody targeting TRIB3. Anti-TRIB3 Antibody (9I365) can be used in WB,IP.

Anti-TRIB3 Antibody (9I365)

Anti-TRIB3 Antibody (9I365)

😃Good
Catalog No. TMAB-13767
Anti-TRIB3 Antibody (9I365) is a Rabbit antibody targeting TRIB3. Anti-TRIB3 Antibody (9I365) can be used in WB,IP.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1517-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4707-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-TRIB3 Antibody (9I365) is a Rabbit antibody targeting TRIB3. Anti-TRIB3 Antibody (9I365) can be used in WB,IP.
Ig Type
IgG
Clone
9I365
Reactivity
Human
Application
WB
IP
Recommended Dose
WB: 1:500-2000; IP: 1:20-50
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
Tissue SpecificityHighest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundInactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress.Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress.
Antigen Details
Immunogen
A synthesized peptide: human TRIB3
Antigen Species
Human
Gene Name
TRIB3
Gene ID
57761
Protein Name
Tribbles homolog 3
Uniprot ID
Q96RU7
Function
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
Chemical Properties
Molecular WeightTheoretical: 40 kDa. Actual: 40 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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