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IL-2-IN-1

🥰Excellent
Catalog No. T62183Cas No. 245747-10-8

IL-2-IN-1 is a potent inhibitor of IL-2 (IC50: 1978 nM) and demonstrates anti-proliferative effects.

IL-2-IN-1

IL-2-IN-1

🥰Excellent
Purity: 99.6%
Catalog No. T62183Cas No. 245747-10-8
IL-2-IN-1 is a potent inhibitor of IL-2 (IC50: 1978 nM) and demonstrates anti-proliferative effects.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$40In StockIn Stock
5 mg$95In StockIn Stock
10 mg$153In StockIn Stock
25 mg$308In StockIn Stock
50 mg$491In StockIn Stock
100 mg$648In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.6%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
IL-2-IN-1 is a potent inhibitor of IL-2 (IC50: 1978 nM) and demonstrates anti-proliferative effects.
Targets&IC50
IL-2:1978 nM, GR (human PBMC):340nM, GR (rat PBMC):1266 nM
In vitro
IL-2-IN-1 is a potent inhibitor of IL-2 synthesis, exhibiting anti-proliferative activity against human PBMC and rat PBMC with IC50 values of 340 and 1266 nM, respectively [1].
Chemical Properties
Molecular Weight418.29
FormulaC17H12F6N4O2
Cas No.245747-10-8
SmilesO=C(NC1=CC=C(C=C1)N2N=C(C=C2C(F)(F)F)C(F)(F)F)C=3C(=NOC3C)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (239.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3907 mL11.9534 mL23.9069 mL119.5343 mL
5 mM0.4781 mL2.3907 mL4.7814 mL23.9069 mL
10 mM0.2391 mL1.1953 mL2.3907 mL11.9534 mL
20 mM0.1195 mL0.5977 mL1.1953 mL5.9767 mL
50 mM0.0478 mL0.2391 mL0.4781 mL2.3907 mL
100 mM0.0239 mL0.1195 mL0.2391 mL1.1953 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ILReceptorIL-2IL Receptor
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