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IL-2-IN-1

Name: IL-2-IN-1
Brand: TargetMol
SKU: T62183
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62183Cas No. 245747-10-8

IL-2-IN-1 is a potent inhibitor of IL-2 (IC50: 1978 nM) and demonstrates anti-proliferative effects.

IL-2-IN-1

🥰Excellent

Purity: 99.6%

Catalog No. T62183Cas No. 245747-10-8

IL-2-IN-1 is a potent inhibitor of IL-2 (IC50: 1978 nM) and demonstrates anti-proliferative effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$95	In Stock	In Stock
10 mg	$153	In Stock	In Stock
25 mg	$308	In Stock	In Stock
50 mg	$491	In Stock	In Stock
100 mg	$648	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	IL-2-IN-1 is a potent inhibitor of IL-2 (IC50: 1978 nM) and demonstrates anti-proliferative effects.
Targets&IC50	IL-2:1978 nM, GR (human PBMC):340nM, GR (rat PBMC):1266 nM
In vitro	IL-2-IN-1 is a potent inhibitor of IL-2 synthesis, exhibiting anti-proliferative activity against human PBMC and rat PBMC with IC50 values of 340 and 1266 nM, respectively [1].

Chemical Properties

Molecular Weight	418.29
Formula	C₁₇H₁₂F₆N₄O₂
Cas No.	245747-10-8
Smiles	O=C(NC1=CC=C(C=C1)N2N=C(C=C2C(F)(F)F)C(F)(F)F)C=3C(=NOC3C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (239.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3907 mL	11.9534 mL	23.9069 mL	119.5343 mL
5 mM	0.4781 mL	2.3907 mL	4.7814 mL	23.9069 mL
10 mM	0.2391 mL	1.1953 mL	2.3907 mL	11.9534 mL
20 mM	0.1195 mL	0.5977 mL	1.1953 mL	5.9767 mL
50 mM	0.0478 mL	0.2391 mL	0.4781 mL	2.3907 mL
100 mM	0.0239 mL	0.1195 mL	0.2391 mL	1.1953 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc