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CD8 alpha Protein, Human, Recombinant (hFc)

Catalog No. TMPY-05364
Synonyms: Leu-2, p32 186910, p32, CD8 α, CD8 alpha, MAL, CD8, CD8a molecule, Leu2

CD8 alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.3 kDa and the accession number is P01732-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD8 alpha Protein, Human, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 451.00
200 μg 5 days $ 798.00
500 μg 5 days $ 1,690.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Testing in progress
Description CD8 alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.3 kDa and the accession number is P01732-1.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number P01732-1
Synonyms Leu-2, p32 186910, p32, CD8 α, CD8 alpha, MAL, CD8, CD8a molecule, Leu2
Construction The Human CD8A (NP_001759.3) (Met1-Asp182) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity > 95 % as determined by SDS-PAGE.

Molecular Weight 44.3 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

References and Literature

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Keywords

CD8 alpha Protein, Human, Recombinant (hFc) Leu-2 p32 186910 p32 CD8 α CD 8 CD8 alpha MAL CD-8 CD8 CD8a molecule Leu2 recombinant recombinant-proteins proteins protein

 

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