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SR 12460

Name: SR 12460
Brand: TargetMol
SKU: T37449
Rating: 4.5 (1 reviews)

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Catalog No. T37449Cas No. 2055101-66-9

Alias SR12460

SR 12460 is a lead NBD mimic, inhibiting the interaction between IKKβ and NEMO, suppressing TNF-α and LPS-induced NF-κB activation, and reducing LPS-induced acute pulmonary inflammation in mice.

SR 12460

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Catalog No. T37449Alias SR12460Cas No. 2055101-66-9

SR 12460 is a lead NBD mimic, inhibiting the interaction between IKKβ and NEMO, suppressing TNF-α and LPS-induced NF-κB activation, and reducing LPS-induced acute pulmonary inflammation in mice.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$197	35 days	35 days
5 mg	$535	35 days	35 days
10 mg	$970	35 days	35 days
25 mg	$2,200	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:Gray

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COA

Product Introduction

Bioactivity

Description	SR 12460 is a lead NBD mimic, inhibiting the interaction between IKKβ and NEMO, suppressing TNF-α and LPS-induced NF-κB activation, and reducing LPS-induced acute pulmonary inflammation in mice.
In vitro	SR 12460 inhibited TNF-α-mediated NF-κB activation with a maximum median inhibitory concentration (IC50) of 11.34 μM. SR 12460 (50 μM) inhibits tumor necrosis factor α (TNF-α) and lipopolysaccharide (LPS) -induced NF-κB activation by blocking the interaction between IKKβ and NEMO. [1]
In vivo	SR 12460 (10 mg/kg, intraperitoneal injection) inhibited LPS-induced acute lung inflammation in mice. SR 12460 (30 mg/kg intraperitoneally administered) significantly improved muscle function and muscle pathology in mdx mice. [1]
Synonyms	SR12460

Chemical Properties

Molecular Weight	325.74
Formula	C₁₅H₁₄ClF₂N₃O
Cas No.	2055101-66-9
Smiles	O=C(NC1=NC=C(Cl)C=C1)CNCCC=2C=C(F)C=C(F)C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 8 mg/mL (24.56 mM), Sonication is recommended.

DMSO: 8 mg/mL (24.56 mM), Sonication is recommended.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0699 mL	15.3497 mL	30.6993 mL	153.4967 mL
5 mM	0.6140 mL	3.0699 mL	6.1399 mL	30.6993 mL
10 mM	0.3070 mL	1.5350 mL	3.0699 mL	15.3497 mL
20 mM	0.1535 mL	0.7675 mL	1.5350 mL	7.6748 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SR-12460SR 12460