Osajin

Name: Osajin
Brand: TargetMol
SKU: T16407
Price: 649 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: NSC-21565, NSC21565, NSC 21565, CID-95168, CID95168, CID 95168) Copy Product Info

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Synonyms: NSC-21565, NSC21565, NSC 21565, CID-95168, CID95168, CID 95168

Catalog No. T16407 Copy Product Info

Purity: 99.18%

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Osajin is an isoflavonoid natural product isolated from the fruits of Maclura pomifera. It belongs to flavonoid derivatives, and studies have reported that it exhibits multiple biological activities, including anticancer, antioxidant, and anti-inflammatory effects.

Cas No. 482-53-1

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$649	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.18%

Appearance:Solid

Color:Green

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Osajin is an isoflavonoid natural product isolated from the fruits of Maclura pomifera. It belongs to flavonoid derivatives, and studies have reported that it exhibits multiple biological activities, including anticancer, antioxidant, and anti-inflammatory effects.
Targets & IC50	BMDMs:12 μg/mL, ACHN cells:12.13 μM (GI50), MDA-MB-231 cells:11.34 μM( GI50), NCI-H23 cells:11.97 μM (GI50), HCT15 cells:9.65 μM (GI50), PC3 cells:12.32 μM (GI50), HeLa cells:6.53 μM, RAW 264.7 cells:7.2 μg/mL
In vitro	Osajin shows growth inhibitory activity on six human cancer cell lines, including kidney, lung, prostate, breast, melanoma and colon cancer cells. Osajin obviously reduces the viability of human NPC cells in a dose-dependent manner. Osajin causes apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress[1][2].
In vivo	The cardioprotective effects of osajin and pomiferin are attributed to their ability to suppress oxidative stress, coinciding with enhanced ventricular function. These compounds mitigate myocardial dysfunction induced by ischemia-reperfusion, evidenced by elevated levels of antioxidant enzymes and overall antioxidant activity[3].
Synonyms	NSC-21565, NSC21565, NSC 21565, CID-95168, CID95168, CID 95168

Chemical Properties

Molecular Weight	404.46
Formula	C₂₅H₂₄O₅
Cas No.	482-53-1
Smiles	O=C1C(=COC=2C=3C=CC(OC3C(=C(O)C12)CC=C(C)C)(C)C)C=4C=CC(O)=CC4
Relative Density.	1.258 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.