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Snail/HDAC-IN-1

Name: Snail/HDAC-IN-1
Brand: TargetMol
SKU: T63260
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63260Cas No. 2415281-52-4

Snail/HDAC-IN-1 is a Snail/HDAC inhibitor with antimicrobial and anticancer activity, known to reduce Snail protein expression and induce apoptosis, making it useful for the study of solid tumors.

Snail/HDAC-IN-1

🥰Excellent

Purity: 97.08%

Catalog No. T63260Cas No. 2415281-52-4

Snail/HDAC-IN-1 is a Snail/HDAC inhibitor with antimicrobial and anticancer activity, known to reduce Snail protein expression and induce apoptosis, making it useful for the study of solid tumors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$455	-	In Stock
50 mg	$655	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.08%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Snail/HDAC-IN-1 is a Snail/HDAC inhibitor with antimicrobial and anticancer activity, known to reduce Snail protein expression and induce apoptosis, making it useful for the study of solid tumors.
Targets&IC50	Colon HCT 116 cells:0.0751 μM, HDAC1:0.405 μM
In vitro	Snail/HDAC-IN-1 exhibited the most potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM, potent inhibition against Snail with a Kd of 0.180 μM, and antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751 μM. Snail/HDAC-IN-1 showed good inhibitory effects on NCI-H522 (GI50 = 0.0488 μM), MDA-MB-435 (GI50 = 0.0361 μM), and MCF7 (GI50 = 0.0518 μM)[1].

Chemical Properties

Molecular Weight	488.54
Formula	C₂₄H₂₁FN₈OS
Cas No.	2415281-52-4
Smiles	O=C(NC1=CC=C(F)C=C1N)C2=CC=C(C=C2)CSC=3N=C(NC4=NNC(=C4)C)C5=CC=CN5N3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (204.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.75 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0469 mL	10.2346 mL	20.4692 mL	102.3458 mL
5 mM	0.4094 mL	2.0469 mL	4.0938 mL	20.4692 mL
10 mM	0.2047 mL	1.0235 mL	2.0469 mL	10.2346 mL
20 mM	0.1023 mL	0.5117 mL	1.0235 mL	5.1173 mL
50 mM	0.0409 mL	0.2047 mL	0.4094 mL	2.0469 mL
100 mM	0.0205 mL	0.1023 mL	0.2047 mL	1.0235 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc