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Snail/HDAC-IN-1

Catalog No. T63260 CAS 2415281-52-4

Snail/HDAC-IN-1 is a Snail/HDAC inhibitor agent with antimicrobial and anticancer activity, reduces Snail protein expression, induces apoptosis, and can be used in the study of solid tumors.

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Snail/HDAC-IN-1, CAS 2415281-52-4

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Description	Snail/HDAC-IN-1 is a Snail/HDAC inhibitor agent with antimicrobial and anticancer activity, reduces Snail protein expression, induces apoptosis, and can be used in the study of solid tumors.
Targets&IC50	HDAC1:0.405 μM, Colon HCT 116 cells:0.0751 μM
In vitro	Snail/HDAC-IN-1 exhibited the most potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM, potent inhibition against Snail with a Kd of 0.180 μM, and antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751 μM. Snail/HDAC-IN-1 showed good inhibitory effects on NCI-H522 (GI50 = 0.0488 μM), MDA-MB-435 (GI50 = 0.0361 μM), and MCF7 (GI50 = 0.0518 μM)[1].

Molecular Weight	488.54
Formula	C24H21FN8OS
CAS No.	2415281-52-4

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (20.47 mM), Sonication is recommended.

References and Literature

1. Cui H, et al. Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer. Eur J Med Chem. 2022;229:114082.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Snail/HDAC-IN-1 2415281-52-4 Apoptosis Microbiology/Virology Antifungal inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.