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Anti-Beta-Catenin Antibody (5O621)

😃Good
Catalog No. TMAB-00229
Alias PRO2286, OK/SW-cl.35, NEDSDV, MRD19, EVR7, CTNNB, beta-catenin, armadillo

Anti-Beta-Catenin Antibody (5O621) is a Mouse antibody targeting Beta-Catenin. Anti-Beta-Catenin Antibody (5O621) can be used in WB.

Anti-Beta-Catenin Antibody (5O621)

Anti-Beta-Catenin Antibody (5O621)

😃Good
Catalog No. TMAB-00229Alias PRO2286, OK/SW-cl.35, NEDSDV, MRD19, EVR7, CTNNB, beta-catenin, armadillo
Anti-Beta-Catenin Antibody (5O621) is a Mouse antibody targeting Beta-Catenin. Anti-Beta-Catenin Antibody (5O621) can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2227-10 days
100 μL$3737-10 days
200 μL$5277-10 days
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Product Introduction

Bioactivity
Description
Anti-Beta-Catenin Antibody (5O621) is a Mouse antibody targeting Beta-Catenin. Anti-Beta-Catenin Antibody (5O621) can be used in WB.
AliasPRO2286, OK/SW-cl.35, NEDSDV, MRD19, EVR7, CTNNB, beta-catenin, armadillo
Ig Type
IgG
Clone
5O621
Reactivity
Human,Mouse,Rat
Verified Activity
1. Sample:
U87Mg (Human) Cell Lysate at 30 μg
U2os (Human) Cell Lysate at 30 μg
Primary: Anti-Beta catenin (TMAB-00229) at 1/5000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 92 kDa
Observed band size: 92 kDa
2. Sample:
Hela (Human) Cell Lysate at 30 μg
NIH/3T3 (Mouse) Cell Lysate at 30 μg
Medulld (Mouse) Lysate at 40 μg
Testis (Mouse) Lysate at 40 μg
Cerebrum (Rat) Lysate at 40 μg
Primary: Anti-Beta catenin (TMAB-00229) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 92 kDa
Observed band size: 95 kDa
Application
WB
Recommended Dose
WB: 1:1000-5000
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Co-localizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundThe protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].
Antigen Details
Immunogen
Recombinant Protein: human Beta catenin
Antigen Species
Human
Gene ID
Uniprot ID
Biology Area
Cytoplasmic,Catenins,Cadherins,beta catenin,Neurogenesis,ChIP antibodies,Leukocyte recruitment,Cadherins
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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