Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PLX7922, a RAF inhibitor, demonstrates binding affinity with BRAF V600E and exhibits inhibitory effects on pERK in BRAF V600E cell lines, while inducing pERK activation in mutant NRAS cell lines.
Description | PLX7922, a RAF inhibitor, demonstrates binding affinity with BRAF V600E and exhibits inhibitory effects on pERK in BRAF V600E cell lines, while inducing pERK activation in mutant NRAS cell lines. |
In vitro | PLX7922, at concentrations ranging from 1 to 1000 nanomoles (nM), effectively inhibits phosphorylated ERK (pERK) in cells expressing the BRAF V600E mutation while concurrently activating pERK in cell lines with mutated NRAS (specifically B9 and IPC-298)[1]. |
Synonyms | PLX7922 |
Molecular Weight | 464.58 |
Formula | C20H25FN6O2S2 |
CAS No. | 1638772-61-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PLX7922 1638772-61-8 PLX-7922 PLX 7922 inhibitor inhibit