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Mirodenafil

Name: Mirodenafil
Brand: TargetMol
SKU: T16079
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SK3530) Copy Product Info

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Synonyms: SK3530

Catalog No. T16079 Copy Product Info

Purity: 99.89%

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Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.

Cas No. 862189-95-5

Pack Size	Price	USA Stock	Global Stock
2 mg	$30	In Stock	In Stock
5 mg	$44	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$136	In Stock	In Stock
50 mg	$222	In Stock	In Stock
100 mg	$355	-	In Stock
200 mg	$523	-	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

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COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.
In vitro	The pharmacoki-netics of mirodenafil were not significantly altered by this concurrent administration. Mirodenafil (50 or 100 mg), obviously improved erectile function and was well tolerated in a representative population of Korean men with broad-spectrum ED of various etiologies and severities [1]. Mirodenafil administered with alcohol had a tolerability profile comparable to that of mirodenafil alone [2]. The concurrent administration of mirodenafil with alcohol was not associated with clinically significant hemodynamic changes in these healthy male volunteers in Korea. The coadministration of ketoconazole and rifampicin resulted in significant changes in systemic exposure to mirodenafil, in these healthy Korean male volunteers [3].
Synonyms	SK3530

Chemical Properties

Molecular Weight	531.67
Formula	C₂₆H₃₇N₅O₅S
Cas No.	862189-95-5
Smiles	C(CC)C=1C2=C(N(CC)C1)C(=O)N=C(N2)C3=C(OCCC)C=CC(S(=O)(=O)N4CCN(CCO)CC4)=C3
Relative Density.	1.33

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247.5 mg/mL (465.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (18.81 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (18.81 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8809 mL	9.4043 mL	18.8087 mL	94.0433 mL
5 mM	0.3762 mL	1.8809 mL	3.7617 mL	18.8087 mL
10 mM	0.1881 mL	0.9404 mL	1.8809 mL	9.4043 mL
20 mM	0.0940 mL	0.4702 mL	0.9404 mL	4.7022 mL
50 mM	0.0376 mL	0.1881 mL	0.3762 mL	1.8809 mL
100 mM	0.0188 mL	0.0940 mL	0.1881 mL	0.9404 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Mirodenafil chemical structure | Mirodenafil in vitro | Mirodenafil formula | Mirodenafil molecular weight