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NLRP3-IN-11

Name: NLRP3-IN-11
Brand: TargetMol
SKU: T61132
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61132Cas No. 2769040-91-5

NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.

NLRP3-IN-11

🥰Excellent

Catalog No. T61132Cas No. 2769040-91-5

NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.

Pack Size	Price	Availability
5 mg	$108	In Stock
10 mg	$158	In Stock
25 mg	$266	In Stock
50 mg	$395	In Stock
100 mg	$587	In Stock

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Batch Information

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Purity:>99.99%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.
Targets&IC50	NLRP3:<0.3 μM
In vitro	NLRP3-IN-11 exhibits biological activity with an IC50 value of <0.3 μM in a human PBMC NLRP3 assay [1].

Chemical Properties

Molecular Weight	344.8
Formula	C₁₇H₁₇ClN₄O₂
Cas No.	2769040-91-5
Smiles	N(CC(C)(C)O)C=1C2=C(C(=NN1)C3=C(O)C=C(Cl)C=C3)C=CN=C2
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (290.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9002 mL	14.5012 mL	29.0023 mL	145.0116 mL
5 mM	0.5800 mL	2.9002 mL	5.8005 mL	29.0023 mL
10 mM	0.2900 mL	1.4501 mL	2.9002 mL	14.5012 mL
20 mM	0.1450 mL	0.7251 mL	1.4501 mL	7.2506 mL
50 mM	0.0580 mL	0.2900 mL	0.5800 mL	2.9002 mL
100 mM	0.0290 mL	0.1450 mL	0.2900 mL	1.4501 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc