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Anti-ASIC1 Antibody
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Catalog No. T9901A-1268 Copy Product Info
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Anti-ASIC1 Antibody is a humanized monoclonal antibody that binds specifically to the extracellular domain of acid-sensing ion channel 1 (ASIC1). This product blocks mediated cation currents (primarily sodium ions), effectively reducing neuronal hyperexcitability and acidotoxicity induced by tissue acidosis. It serves as an important pharmacological tool for researching chronic pain, ischemic stroke, and neurodegenerative diseases.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $377 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-ASIC1 Antibody is a humanized monoclonal antibody that binds specifically to the extracellular domain of acid-sensing ion channel 1 (ASIC1). This product blocks mediated cation currents (primarily sodium ions), effectively reducing neuronal hyperexcitability and acidotoxicity induced by tissue acidosis. It serves as an important pharmacological tool for researching chronic pain, ischemic stroke, and neurodegenerative diseases. |
| In vitro | In electrophysiological and cell-based assays, Anti-ASIC1 Antibody exhibits high binding affinity to the extracellular loop of human ASIC1 and effectively inhibits pH 5.0-evoked inward currents in transfected HEK293 cells or primary cortical neurons in a concentration-dependent manner [1]. |
| In vivo | In pharmacological studies using rodent models of ischemic stroke (such as middle cerebral artery occlusion, MCAO) or inflammatory pain, systemic or central administration of Anti-ASIC1 Antibody resulted in a significant reduction in infarct volume and a marked alleviation of pain-related behaviors by preventing acidotoxicity and neuronal death, demonstrating its potent neuroprotective and analgesic efficacy [1][2]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | ASIC1 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Anti-ASIC1 Antibody chemical structure | Anti-ASIC1 Antibody in vivo | Anti-ASIC1 Antibody in vitro
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