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NSC117079
🥰Excellent
Catalog No. T12260Cas No. 500363-63-3
Alias NSC 117079
NSC117079 is a novel PHLPP1/2 (Pleckstrin homology domain and leucine rich repeat protein phosphatase) inhibitor that activates neuronal AKT and ameliorates staurosporine-induced cell death in neurons.
NSC117079
🥰Excellent
Purity: 98.11%
Catalog No. T12260Alias NSC 117079Cas No. 500363-63-3
NSC117079 is a novel PHLPP1/2 (Pleckstrin homology domain and leucine rich repeat protein phosphatase) inhibitor that activates neuronal AKT and ameliorates staurosporine-induced cell death in neurons.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $63 | In Stock | |
| 5 mg | $139 | In Stock | |
| 10 mg | $226 | In Stock | |
| 25 mg | $480 | In Stock | |
| 50 mg | $789 | In Stock | |
| 100 mg | $1,320 | In Stock | |
| 200 mg | $1,770 | In Stock |
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Purity:98.11%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NSC117079 is a novel PHLPP1/2 (Pleckstrin homology domain and leucine rich repeat protein phosphatase) inhibitor that activates neuronal AKT and ameliorates staurosporine-induced cell death in neurons. |
| In vitro | The in vitro activity of NSC117079 was evaluated in primary rat cortical neurons and astrocytes. Neurons were pretreated with NSC117079 (10–100 μM) for 35 minutes after nutrient deprivation, or co-treated with staurosporine (50–200 nM) for 24 hours; astrocytes were treated for 24 hours after seeding. NSC117079 activated AKT signaling and showed protective effects in neurons, but inhibited signaling and reduced viability in astrocytes [1]. |
| In vivo | The in vivo activity of NSC117079 was evaluated in a mouse model of osteoarthritis induced by destabilization of the medial meniscus (DMM). Twelve-week-old male C57BL/6 mice underwent right knee DMM surgery, followed by a single intra-articular injection of NSC117079 (8 mM, 3 μL; estimated intra-articular concentration ~4 mM) at 7 weeks post-surgery. The results showed that NSC117079 significantly reduced mechanical allodynia, preserved normal activity levels, and slowed articular cartilage degradation [2]. |
| Alias | NSC 117079 |
| Molecular Weight | 473.48 |
| Formula | C20H15N3O7S2 |
| Cas No. | 500363-63-3 |
| Smiles | O=C1C=2C=CC=CC2C(=O)C3=C(C=C(C(N)=C13)S(=O)(=O)O)NC4=CC=CC(=C4)S(=O)(=O)N |
| Relative Density. | 1.696 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (84.48 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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