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NSC117079

Name: NSC117079
Brand: TargetMol
SKU: T12260
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12260Cas No. 500363-63-3

Alias NSC 117079

NSC117079 is a novel PHLPP1/2 (Pleckstrin homology domain and leucine rich repeat protein phosphatase) inhibitor that activates neuronal AKT and ameliorates staurosporine-induced cell death in neurons.

NSC117079

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Purity: 98.11%

Catalog No. T12260Alias NSC 117079Cas No. 500363-63-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	-	In Stock
5 mg	$129	-	In Stock
10 mg	$213	-	In Stock
25 mg	$455	-	In Stock
50 mg	$787	-	In Stock
100 mg	$1,320	-	In Stock
200 mg	$1,770	-	In Stock
1 mL x 10 mM (in DMSO)	$137	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.11%

Appearance:Solid

Color:Brown

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	NSC117079 is a novel PHLPP1/2 (Pleckstrin homology domain and leucine rich repeat protein phosphatase) inhibitor that activates neuronal AKT and ameliorates staurosporine-induced cell death in neurons.
In vitro	The in vitro activity of NSC117079 was evaluated in primary rat cortical neurons and astrocytes. Neurons were pretreated with NSC117079 (10–100 μM) for 35 minutes after nutrient deprivation, or co-treated with staurosporine (50–200 nM) for 24 hours; astrocytes were treated for 24 hours after seeding. NSC117079 activated AKT signaling and showed protective effects in neurons, but inhibited signaling and reduced viability in astrocytes [1].
In vivo	The in vivo activity of NSC117079 was evaluated in a mouse model of osteoarthritis induced by destabilization of the medial meniscus (DMM). Twelve-week-old male C57BL/6 mice underwent right knee DMM surgery, followed by a single intra-articular injection of NSC117079 (8 mM, 3 μL; estimated intra-articular concentration ~4 mM) at 7 weeks post-surgery. The results showed that NSC117079 significantly reduced mechanical allodynia, preserved normal activity levels, and slowed articular cartilage degradation [2].
Synonyms	NSC 117079

Chemical Properties

Molecular Weight	473.48
Formula	C₂₀H₁₅N₃O₇S₂
Cas No.	500363-63-3
Smiles	O=C1C=2C=CC=CC2C(=O)C3=C(C=C(C(N)=C13)S(=O)(=O)O)NC4=CC=CC(=C4)S(=O)(=O)N
Relative Density.	1.696 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (84.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1120 mL	10.5601 mL	21.1202 mL	105.6011 mL
5 mM	0.4224 mL	2.1120 mL	4.2240 mL	21.1202 mL
10 mM	0.2112 mL	1.0560 mL	2.1120 mL	10.5601 mL
20 mM	0.1056 mL	0.5280 mL	1.0560 mL	5.2801 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1120 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc