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Argifin

Name: Argifin
Brand: TargetMol
SKU: TP2140
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TP2140 Copy Product Info

Purity: 99.86%

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Argifin is a chitinase inhibitor produced by the metabolism of soil microorganisms, with inhibitory activity at the sub-nanomolar level; its IC50 values against Serratia marcescens chitinase A and B, Aspergillus fumigatus chitinase B1 and human chitotriosidase are 0.025 μM, 6.4 μM, 1.1 μM and 4.5 μM, respectively [1].

Argifin

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Catalog No. TP2140

Cas No. 243975-37-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$98	-	In Stock
5 mg	$277	-	In Stock
10 mg	$428	-	In Stock
25 mg	$698	-	In Stock
50 mg	$968	-	In Stock
100 mg	$1,280	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.86%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Argifin is a chitinase inhibitor produced by the metabolism of soil microorganisms, with inhibitory activity at the sub-nanomolar level; its IC50 values against Serratia marcescens chitinase A and B, Aspergillus fumigatus chitinase B1 and human chitotriosidase are 0.025 μM, 6.4 μM, 1.1 μM and 4.5 μM, respectively [1].
Targets&IC50	SmChiB:6.4 μM , Chitotriosidase (human):4.5 μM , Chitinase B1 (aspergillus fumigatus):1.1 μM , SmChiA:0.025 μM , SmChiA:0.025 μM, SmChiB:6.4 μM, Chitinase B1 (aspergillus fumigatus):1.1 μM, Chitotriosidase (human):4.5 μM
In vitro	Methods: The inhibitory activity of Argifin against L. cuprina chitinase was determined at 37 °C and 20 °C. Results: Argifin inhibited L. cuprina chitinase, with an IC₅₀ of 3.7 μM at 37 °C and 0.10 μM at 20 °C[1].
In vivo	Methods: L. cuprina was treated with Argifin. Results: Argifin exhibited inhibitory effects on the ecdysis of L. cuprina[1].

Chemical Properties

Molecular Weight	675.70
Formula	C₂₉H₄₁N₉O₁₀
Cas No.	243975-37-3
Smiles	C([C@@H]1N(C)C(=O)[C@H](CCCNC(NC(NC)=O)=N)NC(=O)[C@@H](C)NC(=O)C[C@@H](C(O)=O)NC(=O)C[C@@H](C(O)=O)NC1=O)C2=CC=CC=C2
Relative Density.	1.49 g/cm3 (Predicted)
Sequence	Cyclo({d-Ala}-{N5-[imino[[(methylamino)carbonyl]amino]methyl]-L-ornithyl}-{Phe(Me)}-{Bas}-{Bas})
Sequence Short	Cyclo({d-Ala}-{N5-[imino[[(methylamino)carbonyl]amino]methyl]-L-ornithyl}-{Phe(Me)}-{Bas}-{Bas})

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (118.40 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4799 mL	7.3997 mL	14.7995 mL	73.9973 mL
5 mM	0.2960 mL	1.4799 mL	2.9599 mL	14.7995 mL
10 mM	0.1480 mL	0.7400 mL	1.4799 mL	7.3997 mL
20 mM	0.0740 mL	0.3700 mL	0.7400 mL	3.6999 mL
50 mM	0.0296 mL	0.1480 mL	0.2960 mL	1.4799 mL
100 mM	0.0148 mL	0.0740 mL	0.1480 mL	0.7400 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc