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PROTAC TG2 degrader-2

Catalog No. T79315

PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovarian cancer cells, making it a valuable tool for ovarian cancer research [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PROTAC TG2 degrader-2 Chemical Structure

PROTAC TG2 degrader-2, CAS N/A

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

PROTAC TG2 degrader-2 (Compound 7) (10 μΜ, up to 24 h) inhibits migration in wound healing and invasion assays of OVCAR5 and SKOV3 cell lines [1]. Additionally, at 10 μΜ, it reduces the adherence of these cells to fibronectin [1]. When administered up to 10 μΜ for 6 h, it decreases the levels of transglutaminase 2 (TG2) in a concentration-dependent manner within 6 h in both OVCAR5 and SKOV3 cells [1].

Molecular Weight	876.08
Formula	C47H57N9O6S

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PROTAC TG2 degrader-2 PROTAC PROTACs inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.