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Sparfosic acid trisodium

Name: Sparfosic acid trisodium
Brand: TargetMol
SKU: T12983
Price: 799 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12983Cas No. 70962-66-2

Sparfosic acid trisodium is a CAD (carbamoyl-phosphate synthetase 2) inhibitor and also an aspartate transcarbamoyl transferase inhibitor with antitumour activity.

Sparfosic acid trisodium

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Catalog No. T12983Cas No. 70962-66-2

Sparfosic acid trisodium is a CAD (carbamoyl-phosphate synthetase 2) inhibitor and also an aspartate transcarbamoyl transferase inhibitor with antitumour activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$799	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:Gray

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COA

Product Introduction

Bioactivity

Description	Sparfosic acid trisodium is a CAD (carbamoyl-phosphate synthetase 2) inhibitor and also an aspartate transcarbamoyl transferase inhibitor with antitumour activity.
In vitro	Method: Br-1 and L-2 cell lines, established from metastases in nude mice injected with the human tumor cell line MDA-MB-435, were treated with Sparfosic acid trisodium (300 µM) for 12, 24, and 48 hours to evaluate its effects on the cell cycle. Result: Following treatment, both cell lines were predominantly arrested in the S phase, with a slightly higher proportion of S phase cells observed in L-2 compared to Br-1 cells. [1]
In vivo	Method: Sparfosic acid trisodium was administered intraperitoneally at a dose of 490 mg/kg on days 1, 5, and 9 to tumor-bearing mice implanted with either B16 melanoma or Lewis lung carcinoma, to evaluate its antitumor efficacy. Result: In the B16 melanoma model, Sparfosic acid trisodium extended mouse survival by 77%–86% compared to controls. In the Lewis lung carcinoma model, the compound showed high sensitivity; subcutaneous administration on days 1, 5, and 9 Resulted in a 50% cure rate in tumor-bearing mice. [3]

Chemical Properties

Molecular Weight	277.1
Formula	C₆H₉NNaO₈P
Cas No.	70962-66-2
Smiles	O=P([O-])(O)CC(N[C@H](C(O)=O)CC(O)=O)=O.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (577.41 mM), Sonication is recommended.

H2O: 200 mg/mL (721.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (18.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.6088 mL	18.0440 mL	36.0881 mL	180.4403 mL
5 mM	0.7218 mL	3.6088 mL	7.2176 mL	36.0881 mL
10 mM	0.3609 mL	1.8044 mL	3.6088 mL	18.0440 mL
20 mM	0.1804 mL	0.9022 mL	1.8044 mL	9.0220 mL
50 mM	0.0722 mL	0.3609 mL	0.7218 mL	3.6088 mL
100 mM	0.0361 mL	0.1804 mL	0.3609 mL	1.8044 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc