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PCC0208017

Name: PCC0208017
Brand: TargetMol
SKU: T40249
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40249Cas No. 2623158-64-3

PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.

PCC0208017

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Purity: 99.48%

Catalog No. T40249Cas No. 2623158-64-3

PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
5 mg	$239	In Stock	In Stock
10 mg	$383	In Stock	In Stock
25 mg	$712	-	In Stock
50 mg	$1,080	-	In Stock
1 mL x 10 mM (in DMSO)	$263	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.48%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.
In vitro	PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7 nM, respectively. PCC0208017 (1-5 μM) decreases the phosphorylation of Tau. PCC0208017 (3-21 μM) suppresses the proliferation of glioma cells[1].
In vivo	In C57BL/6 mice bearing murine glioma GL261 xenograft tumor, PCC0208017 (50 and 100 mg/kg; oral) dose-dependently inhibits the growth of xenograft tumors derived with inhibition rates of 56.15% and 70.32%, respectively. PCC0208017 (50 mg/kg; oral) exhibits Cmax and Tmax of 1.36 μg/mL and 0.833 h in plasma and 0.14 μg/mL and 0.833 h in brain[1]. Co-treatment of PCC0208017 (50 mg/kg) significantly enhances the anti-tumor activity of Temozolomide (100 mg/kg) with inhibition rates from 34.15% to 83.5%[1].

Chemical Properties

Molecular Weight	403.4
Formula	C₁₉H₂₀F₃N₇
Cas No.	2623158-64-3
Smiles	CN1CCc2cc(Nc3ncc(c(NCc4cc[nH]n4)n3)C(F)(F)F)ccc2C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (278.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4789 mL	12.3946 mL	24.7893 mL	123.9465 mL
5 mM	0.4958 mL	2.4789 mL	4.9579 mL	24.7893 mL
10 mM	0.2479 mL	1.2395 mL	2.4789 mL	12.3946 mL
20 mM	0.1239 mL	0.6197 mL	1.2395 mL	6.1973 mL
50 mM	0.0496 mL	0.2479 mL	0.4958 mL	2.4789 mL
100 mM	0.0248 mL	0.1239 mL	0.2479 mL	1.2395 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc