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Trofosfamide

Name: Trofosfamide
Brand: TargetMol
SKU: T17172
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17172Cas No. 22089-22-1

Trofosfamide is a derivative of oxazaphosphorine with antineoplastic potency.

Trofosfamide

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Purity: 98.5%

Catalog No. T17172Cas No. 22089-22-1

Trofosfamide is a derivative of oxazaphosphorine with antineoplastic potency.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$36	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.5%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Trofosfamide AI Summary

Trofosfamide exhibits a broad spectrum of bioactivities, primarily as an inhibitor of various kinases including MEK1 and MEK2, with IC50 values of 70.0 nM and 60.0 nM, respectively. It also antagonizes AP-1 transcriptional activity with an IC50 of 1000.0 nM, and demonstrates inhibition of MEK1 phosphorylation in the BRAF-MEK1 cascading pathway with an IC50 of 210.0 nM. Trofosfamide shows antiviral activity against Influenza A Virus (IAV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and displays significant anticancer activity against several human cancer cell lines, including DLD-1, HCT-116, A549, A375, and HL60, with IC50 values ranging from 300.0 nM to 32200.0 nM. In addition, it activates MEK1/2 activity but inhibits MEK5 activity in HEK293 cells, and induces apoptosis and cell cycle arrest in various human cancer cell lines. Trofosfamide also inhibits other kinases and enzymes involved in cellular processes, such as p38-regulated activated kinase (PRAK) and protein kinase PRAK, enhancing its potential as a multi-target inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Trofosfamide is a derivative of oxazaphosphorine with antineoplastic potency.

Chemical Properties

Molecular Weight	323.58
Formula	C₉H₁₈Cl₃N₂O₂P
Cas No.	22089-22-1
Smiles	N(CCCl)(CCCl)P1(=O)N(CCCl)CCCO1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (293.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0904 mL	15.4521 mL	30.9043 mL	154.5213 mL
5 mM	0.6181 mL	3.0904 mL	6.1809 mL	30.9043 mL
10 mM	0.3090 mL	1.5452 mL	3.0904 mL	15.4521 mL
20 mM	0.1545 mL	0.7726 mL	1.5452 mL	7.7261 mL
50 mM	0.0618 mL	0.3090 mL	0.6181 mL	3.0904 mL
100 mM	0.0309 mL	0.1545 mL	0.3090 mL	1.5452 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc