TL1A/TNFSF15 Protein, Human, Recombinant (rFc)

Catalog No. TMPY-04978 Copy Product Info

TL1A Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 48 kDa and the accession number is A0A0U5JA19.

TL1A/TNFSF15 Protein, Human, Recombinant (rFc)

Catalog No. TMPY-04978

Copy Product Info

TL1A Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 48 kDa and the accession number is A0A0U5JA19.

TL1A/TNFSF15 Protein, Human, Recombinant (rFc)

Pack Size	Price	USA Stock	Global Stock
5 μg	$63	7-10 days	7-10 days
10 μg	$98	7-10 days	7-10 days
20 μg	$163	7-10 days	7-10 days
50 μg	$323	7-10 days	7-10 days
100 μg	$625	7-10 days	7-10 days
200 μg	$987	7-10 days	7-10 days
500 μg	$2,390	7-10 days	7-10 days
1 mg	$5,280	7-10 days	7-10 days

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In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Information

Biological Activity	Measured by its ability to induce apoptosis of TF1 human erythroleukemic cells. The ED50 for this effect is typically 20-120 ng/mL.
Description	TL1A Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 48 kDa and the accession number is A0A0U5JA19.
Species	Human
Expression System	HEK293 Cells
Tag	N-rFc
Accession Number	O95150-1
Synonyms	VEGI192A,VEGI,tumor necrosis factor (ligand) superfamily, member 15,TL1A,TL1
Construction	A DNA sequence encoding the human TNFSF15 (NP_005109.2) (Leu72-Leu251) was expressed with the Fc region of rabbit IgG at the N-terminus.. Predicted N terminal: Ser
Protein Purity	> 90 % as determined by SDS-PAGE.
Molecular Weight	48 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.